Sialic acid synthase Antibodies

AND NANS ELISA kits, Sialic acid synthase Proteins

Many biological assays use antibodies to detect Sialic acid synthase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sialic acid synthase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sialic acid synthase antibodies...

We validate the specificity of these antibodies to Sialic acid synthase by testing them on tissues known to express NANS positively and negatively. Browse below to find the NANS antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NANS Infographic by Boster Bio

All NANS Products

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Product

Figures

Specificity

Applications

Price

Anti-Sialic acid synthase NANS Antibody

Western blot analysis of extracts of various cell lines, using NANS antibody at 1:3000 dilution

Human

$405
Cat # A08540
100ul

NANS (NM_018946) Human Recombinant Protein

Coomassie blue staining of purified NANS protein

$1249
Cat # PROTQ9NR45
20 µg

NANS (NM_018946) Human Over-expression Lysate

Human

$628
Cat # LS054187
20 µg, 100 µg

Anti-NANS Antibody Picoband®

Western blot analysis of NANS using anti-NANS antibody (A08540-2)

IF analysis of NANS using anti-NANS antibody (A08540-2)

Human, Rat

ELISA, IF, ICC, WB

$370
Cat # A08540-2
100 μg/vial

NANS Overview

Facts about Sialic acid synthase.

NANS 3D structure. Source: alphafold

Sialic acid synthase (NANS)

Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to create phosphorylated forms of Neu5Ac and KDN, respectively.

Gene Information

Human
Gene Name:	NANS
Uniprot:	Q9NR45
Entrez:	54187

Family

Belongs to:

No superfamily

Alternative Names

EC 2.5.1.56; EC 2.5.1.57; N-acetylneuraminate synthase; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthasesialic acid phosphate synthase; SASsialic acid synthase

Molecular Weight

Mass (kDA):
40.308 kDA

Genomic Context


Human

Location:	9q22.33
Sequence:	9; NC_000009.12 (98056728..98083083)

Tissue Specificity

Ubiquitous.

Diseases

Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Malignant Neoplasms
Melanoma
Pigmentation Disorders
Hyperplasia

Open Bite

Pathways

Response To Oxidative Stress
Pigmentation

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NANS

References

PMID: 10749855 by Lawrence S.M., et al. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability.

PMID: 27213289 by van Karnebeek C.D., et al. NANS-mediated synthesis of sialic acid is required for brain and skeletal development.