NASP Antibodies

AND NASP ELISA kits, NASP Proteins

Many biological assays use antibodies to detect NASP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NASP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NASP antibodies...

We validate the specificity of these antibodies to NASP by testing them on tissues known to express NASP positively and negatively. Browse below to find the NASP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for NASP? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the NASP IHC Guide

NASP Infographic by Boster Bio

All NASP Products

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Anti-NASP antibody Picoband®

Western blot analysis of NASP using anti-NASP antibody (A05383-1)

IHC analysis of NASP using anti-NASP antibody (A05383-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # A05383-1
100 μg/vial

NASP (NM_002482) Human Over-expression Lysate

Human

$628
Cat # LS004678
20 µg, 100 µg

NASP Overview

Facts about Nuclear autoantigenic sperm protein.

NASP 3D structure. Source: alphafold

Nuclear autoantigenic sperm protein (NASP)

Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity.

NASP and H1 histone are subsequently released from the complex and translocate to the nucleus in which the histone is discharged for binding to DNA. .

Gene Information

Human
Gene Name:	NASP
Uniprot:	P49321
Entrez:	4678

Family

Belongs to:

NASP family

Alternative Names

DKFZp547F162; FLB7527; FLJ31599; FLJ35510; histone H1-binding protein; MGC19722; MGC20372; MGC2297; nuclear autoantigenic sperm protein (histone-binding); nuclear autoantigenic sperm protein; PRO1999

Molecular Weight

Mass (kDA):
85.238 kDA

Genomic Context


Human

Location:	1p34.1
Sequence:	1; NC_000001.11 (45583988..45618906)

Tissue Specificity

Isoform 1 is testis- and sperm-specific.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Malignant Neoplasms
Infertility
Hemorrhage
Neoplasms
Mammary Neoplasms
Ovarian Neoplasm
Inflammation
Sequelae Aspects
Malignant Neoplasm Of Ovary
Gall Bladder Diseases
Epithelial Metaplasia
Malignant Neoplasm Of Breast

Malignant Tumor Of Cervix
Perforation Of Gallbladder
Carcinoma
Rheumatism
Fibrosis
Nephritis
Wounds, Penetrating

Interacting Proteins

H3F3A
H3F3C
HIST1H3A
HIST3H3
TERF2IP

Pathways

Cell Cycle
Localization
Spermatogenesis
Fertilization
Transport
Chromatin Remodeling
Cell Proliferation
Chromatin Assembly
Meiosis
Cell Division
Dna Replication
Pachytene
Immune Response

Translation
Nuclear Import
Rna Processing
Cell Adhesion
Gluconeogenesis
Sex Determination
Reflex

PTMs

Sumoylation

Phosphorylation

Acetylation

Research Areas

Core ESC-Like Genes
DNA Repair
DNA replication, Transcription, Translation and Splicing
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NASP

References

PMID: 1426632 by O'Rand M.G., et al. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein.

PMID: 8724350 by Batova I., et al. Histone-binding domains in a human nuclear autoantigenic sperm protein.