Condensin complex subunit 1 (NCAPD2)

The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May aim the condensin complex to DNA via its C-terminal domain (PubMed:11136719).

May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin- mediated compaction probably increases tension in catenated sister chromatids, providing directionality for type II topoisomerase- mediated strand exchanges toward chromatid decatenation.