NCBP3 Antibodies

AND NCBP3 ELISA kits, NCBP3 Proteins

Many biological assays use antibodies to detect NCBP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCBP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCBP3 antibodies...

We validate the specificity of these antibodies to NCBP3 by testing them on tissues known to express NCBP3 positively and negatively. Browse below to find the NCBP3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCBP3 Infographic by Boster Bio

All NCBP3 Products

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C17orf85 (NCBP3) (NM_001114118) Human Over-expression Lysate

Human

$628
Cat # LS055421
20 µg, 100 µg

C17orf85 (NCBP3) (NM_018553) Human Recombinant Protein

Coomassie blue staining of purified C17orf85 protein

$1249
Cat # PROTQ53F19
20 µg

NCBP3 Overview

Facts about Nuclear cap-binding protein subunit 3.

NCBP3 3D structure. Source: alphafold

Nuclear cap-binding protein subunit 3 (NCBP3)

Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays an integral role in mRNA export. NCBP3 functions as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80.

Unlike the conventional CBC with NCBP2 which contrasts both small nuclear RNA (snRNA) and messenger (mRNA) and is included in their export from the nucleus, the alternative CBC with NCBP3 doesn't bind snRNA and associates only with mRNA thereby playing a part in only mRNA export. The alternative CBC is very important in cellular stress situations like virus infections and the NCBP3 activity is critical to inhibit virus growth (PubMed:26382858).

Gene Information

Human
Gene Name:	NCBP3
Uniprot:	Q53F19
Entrez:	55421

Family

Belongs to:

NCBP3 family

Alternative Names

Chromosome 17 Open Reading Frame 85; ELG Protein; HSA277841; Protein ELG; Uncharacterized Protein C17orf85

Molecular Weight

Mass (kDA):
70.593 kDA

Genomic Context


Human

Location:	17p13.2
Sequence:	17; NC_000017.11 (3802158..3846246, complement)

Subcellular Localizations

Nucleus. Cytoplasm.

Interacting Proteins

KPNA4
LENG8
NCBP1

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCBP3

References

PMID: 26382858 by Gebhardt A., et al. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.