NCEH1 Antibodies

AND NCEH1 ELISA kits, NCEH1 Proteins

Many biological assays use antibodies to detect NCEH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCEH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCEH1 antibodies...

We validate the specificity of these antibodies to NCEH1 by testing them on tissues known to express NCEH1 positively and negatively. Browse below to find the NCEH1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCEH1 Infographic by Boster Bio

All NCEH1 Products

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Specificity

Applications

Price

AADACL1 (NCEH1) (NM_020792) Human Recombinant Protein

Coomassie blue staining of purified NCEH1 protein

$1062
Cat # PROTQ6PIU2
20 µg

AADACL1 (NCEH1) (NM_020792) Human Over-expression Lysate

Human

$628
Cat # LS057552
20 µg, 100 µg

Anti-AADACL1/NCEH1 Antibody Picoband®

Western blot analysis of AADACL1/NCEH1 using anti-AADACL1/NCEH1 antibody (A06478-1)

Flow Cytometry analysis of HepG2 cells using anti-AADACL1/NCEH1 antibody (A06478-1)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A06478-1
100 µg/vial

NCEH1 Overview

Facts about Neutral cholesterol ester hydrolase 1.

NCEH1 3D structure. Source: alphafold

Neutral cholesterol ester hydrolase 1 (NCEH1)

Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May cause cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis.

Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.

Gene Information

Human
Gene Name:	NCEH1
Uniprot:	Q6PIU2
Entrez:	57552

Family

Belongs to:

GDXG' lipolytic enzyme family

Alternative Names

AADACL1; EC 3.1.1.79; KIAA1363EC 3.1.1; NCEHArylacetamide deacetylase-like 1EC 3.1.1.-; neutral cholesterol ester hydrolase 1

Molecular Weight

Mass (kDA):
45.808 kDA

Genomic Context


Human

Location:	3q26.31
Sequence:	3; NC_000003.12 (172630249..172711067, complement)

Tissue Specificity

Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines.

Subcellular Localizations

Membrane; Single-pass type II membrane protein. Microsome.

Diseases

Atherosclerosis
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Prostate
Inflammation
Ovarian Neoplasm
Cell Invasion
Neoplasm Invasiveness
Hyperinsulinism
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent

Cardiovascular Diseases
Prostatic Neoplasms
Aortic Diseases
Hepatotoxicity
Invasive Malignant Neoplasm

Pathways

Transport
Cholesterol Efflux
Cholesterol Transport
Reverse Cholesterol Transport
Cell Migration
Sterol Acetylation
Aging
Pathogenesis

Localization
Secretion
Sterol Homeostasis

PTMs

Phosphorylation
Cleavage

Deacetylation
Acetylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCEH1

References

PMID: 12149457 by Jessani N., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness.

PMID: 17052608 by Chiang K.P., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.