NCKAP1L Antibodies

AND NCKAP1L ELISA kits, NCKAP1L Proteins

Many biological assays use antibodies to detect NCKAP1L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCKAP1L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCKAP1L antibodies...

We validate the specificity of these antibodies to NCKAP1L by testing them on tissues known to express NCKAP1L positively and negatively. Browse below to find the NCKAP1L antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCKAP1L Infographic by Boster Bio

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NCKAP1L Overview

Facts about Nck-associated protein 1-like.

NCKAP1L 3D structure. Source: alphafold

Nck-associated protein 1-like (NCKAP1L)

Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, in addition to phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648).

Part of the WAVE2 complex which signals downstream of RAC to excite F- actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity).

Gene Information

Human
Gene Name:	NCKAP1L
Uniprot:	P55160
Entrez:	3071

Family

Belongs to:

HEM-1/HEM-2 family

Alternative Names

Hematopoietic protein 1HEM1Membrane-associated protein HEM-1; NCK-associated protein 1-like

Molecular Weight

Mass (kDA):
128.153 kDA

Genomic Context


Human

Location:	12q13.13-q13.2
Sequence:	12; NC_000012.12 (54497752..54548243)

Tissue Specificity

Expressed only in cells of hematopoietic origin (PubMed:7643388, PubMed:1932118). Expressed in neutrophils (at protein level) (PubMed:16417406).

Subcellular Localizations

Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm. Localizes to the leading edge of polarized neutrophils.

Diseases

Tissue Adhesions
Wiskott-aldrich Syndrome
Rectal Carcinoma
Fracture Of First Cervical Vertebra
Multiple Malignancy
Glioblastoma
Protrusion
Sterility
Malignant Neoplasms
Hemorrhage

Nervousness
Leukemia
Malignant Neoplasm Of Ovary
Lymphoid Leukemia
Chronic Lymphocytic Leukemia

Pathways

Methylation
Cell Proliferation
Chemotaxis
Phagocytosis
Cell Motility
Neutrophil Chemotaxis
Dna Methylation
Immune Response
Pathogenesis

Oogenesis
Cell-cell Adhesion
Actin Nucleation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCKAP1L

References

PMID: 1932118 by Hromas R., et al. Hem-1, a potential membrane protein, with expression restricted to blood cells.

PMID: 7643388 by Baumgartner S., et al. The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.