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- Table of Contents
Facts about Nck-associated protein 1-like.
Part of the WAVE2 complex which signals downstream of RAC to excite F- actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity).
Human | |
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Gene Name: | NCKAP1L |
Uniprot: | P55160 |
Entrez: | 3071 |
Belongs to: |
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HEM-1/HEM-2 family |
Hematopoietic protein 1HEM1Membrane-associated protein HEM-1; NCK-associated protein 1-like
Mass (kDA):
128.153 kDA
Human | |
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Location: | 12q13.13-q13.2 |
Sequence: | 12; NC_000012.12 (54497752..54548243) |
Expressed only in cells of hematopoietic origin (PubMed:7643388, PubMed:1932118). Expressed in neutrophils (at protein level) (PubMed:16417406).
Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm. Localizes to the leading edge of polarized neutrophils.
PMID: 1932118 by Hromas R., et al. Hem-1, a potential membrane protein, with expression restricted to blood cells.
PMID: 7643388 by Baumgartner S., et al. The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.