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- Table of Contents
NCOR2 Antibodies
AND NCOR2 ELISA kits, NCOR2 Proteins
Many biological assays use antibodies to detect NCOR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOR2 antibodies...
Designing an IHC experiment for NCOR2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NCOR2 IHC GuideNCOR2 Infographic by Boster Bio
All NCOR2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01412-3
100 μg/vial
Cat # A01412-3
100 μg/vial
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01412-2
100 µg/vial
Cat # A01412-2
100 µg/vial
NCOR2 Overview
Facts about Nuclear receptor corepressor 2.
Nuclear receptor corepressor 2 (NCOR2)
Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.
Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal centre (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCOR2 |
| Uniprot: | Q9Y618 |
| Entrez: | 9612 |
Family
| Belongs to: |
|---|
| N-CoR nuclear receptor corepressors family |
Alternative Names
CTG repeat protein 26; CTG26; CTG26nuclear receptor co-repressor 2; FLJ25011; NCOR2; N-CoR2; nuclear receptor corepressor 2; retinoic-acid-receptor-associated corepressor; silencing mediator for retinoid and thyroid hormone receptors; SMAP270; SMRT; SMRTE; SMRTE-tau; SMRTT3 receptor-associating factor; TNRC14; TRAC; TRAC1; TRAC-1
Molecular Weight
Mass (kDA):
273.657 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.31 |
| Sequence: | 12; NC_000012.12 (124324415..124567612, complement) |
Tissue Specificity
Ubiquitous. High levels of expression are detected in lung, spleen and brain.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Leukemia
- Mammary Neoplasms
- Acute Promyelocytic Leukemia
- Malignant Neoplasm Of Prostate
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Prostatic Neoplasms
- Carcinoma
- Refractory Anemia With Ringed Sideroblasts
- Chromosomal Translocation
Interacting Proteins
- AHR
- ARNT
- E2F1
- Gmnn
- HDAC1
- HDAC3
- RARA
- RBPJ
- SNW1
- SPEN
Pathways
- Cell Cycle
- Localization
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Histone Deacetylation
- Cell Differentiation
- Chromatin Remodeling
- Histone Acetylation
- Oncogenesis
- Gene Silencing
- Chromatin Modification
- Cholesterol Homeostasis
PTMs
- Phosphorylation
- Acetylation
- Deacetylation
Research Areas
- Cancer
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOR2
bosterbio.com/bosterbio-gene-info-cards/NCOR2
References
PMID: 8813722 by Sande S., et al. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors.
PMID: 10077563 by Ordentlich P., et al. Unique forms of human and mouse nuclear receptor corepressor SMRT.