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- Table of Contents
Norrin Antibodies
AND NDP ELISA kits, Norrin Proteins
Many biological assays use antibodies to detect Norrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Norrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Norrin antibodies...
Designing a Western blot for Norrin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NDP Western Blot GuideNDP Infographic by Boster Bio
All NDP Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05876-1
100 μg/vial
Cat # A05876-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M05876-2
100 μg/vial
Cat # M05876-2
100 μg/vial
Human Norrin Recombinant Protein
1 Citations
SDS-PAGE, Denatured
$250
Cat # PROTQ00604
Starting from 10ug
Cat # PROTQ00604
Starting from 10ug
NDP Overview
Facts about Norrin.
Norrin (NDP)
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and triggering LEF/TCF-mediated transcriptional programs.
Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, implying the occurrence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation.
Gene Information
| Human | |
|---|---|
| Gene Name: | NDP |
| Uniprot: | Q00604 |
| Entrez: | 4693 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EVR2; exudative vitreoretinopathy 2 (X-linked); FEVR; ND; NDP; Norrie disease (pseudoglioma); Norrie disease protein; Norrin; X-linked exudative vitreoretinopathy 2 protein
Molecular Weight
Mass (kDA):
15.044 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.3 |
| Sequence: | X; NC_000023.11 (43948776..43973390, complement) |
Tissue Specificity
Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Norrie Disease
- Carcinoma
- Blind Vision
- Retinal Diseases
- Malignant Squamous Cell Neoplasm
- Complete Hearing Loss
- Malignant Neoplasm Of Breast
- Lung Neoplasms
- Retinal Detachment
Interacting Proteins
- FZD4
Pathways
- Localization
- Cell Proliferation
- Angiogenesis
- Transport
- Secretion
- Pathogenesis
- Translation
- Cell Growth
- Cell Cycle
- Dna Repair
- Excretion
- Dna Replication
- Insulin Secretion
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Oxidation
- Deamination
- Reduction
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDP
bosterbio.com/bosterbio-gene-info-cards/NDP
References
PMID: 1303235 by Berger W., et al. Isolation of a candidate gene for Norrie disease by positional cloning.
PMID: 1303236 by Chen Z.-Y., et al. Isolation and characterization of a candidate gene for Norrie disease.