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NFE4 Antibodies
AND NFE4 ELISA kits, NFE4 Proteins
Many biological assays use antibodies to detect NFE4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFE4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFE4 antibodies...
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NFE4 Overview
Facts about Transcription factor NF-E4.
Transcription factor NF-E4 (NFE4)
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) from the proximal gamma-globin promoter.
In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NFE4 |
| Uniprot: | Q86UQ8 |
| Entrez: | 58160 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Transcription factor NF-E4
Molecular Weight
Mass (kDA):
19.019 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (102973430..102978667) |
Tissue Specificity
Specifically expressed in fetal liver, cord blood and bone marrow. Also expressed in the K562 and HEL cell lines, which constitutively express the fetal globin genes.
Subcellular Localizations
Nucleus.
Interacting Proteins
- PRMT5
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFE4
bosterbio.com/bosterbio-gene-info-cards/NFE4
References
PMID: 11003662 by Zhou W., et al. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4.
PMID: 16263792 by Zhao Q., et al. Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter.