NF-kappa-B inhibitor beta (NFKBIB)

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation can bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation.

Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation making it more resistant to degradation, describing its slower degradation. .