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Nkx1-2 Antibodies
AND Nkx1-2 ELISA kits, Nkx1-2 Proteins
Many biological assays use antibodies to detect Nkx1-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nkx1-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nkx1-2 antibodies...
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Nkx1-2 Infographic by Boster Bio
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Nkx1-2 Overview
Facts about NK1 transcription factor-related protein 2.
NK1 transcription factor-related protein 2 (Nkx1-2)
May function in cell specification, particularly in the CNS. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Nkx1-2 |
| Uniprot: | P42580 |
| Entrez: | 20231 |
Family
| Belongs to: |
|---|
| NK-1 homeobox family |
Alternative Names
bB238F13.2; C10orf121; NKX-1.1; NKX1-2 NK1 homeobox 2
Molecular Weight
Mass (kDA):
32.013 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 7|7 F3 |
| Sequence: | 7; |
Tissue Specificity
Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain.
Diseases
- Growth Retardation
- Nervousness
- Cholangiocarcinoma
- Insulin Resistance
- Obesity
- Embryonal Carcinoma
- Crest Syndrome
Pathways
- Regulation Of Energy Homeostasis
- Energy Homeostasis
- Cell Differentiation
- Somitogenesis
- Feeding Behavior
- Neurogenesis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nkx1-2
bosterbio.com/bosterbio-gene-info-cards/Nkx1-2
References
PMID: 7669696 by Schubert F.R., et al. Expression of the novel murine homeobox gene Sax-1 in the developing nervous system.
PMID: 10681422 by Rovescalli A.C., et al. The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites.