NLR family pyrin domain-containing protein 2B (NLRP2B)

May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation in'Ser-536', thereby inhibiting its transcriptional activity. During NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity.

May also play a role in cell cycle progression and apoptotic procedure. .