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- Table of Contents
Facts about Notch homolog 2 N-terminal-like protein B.
Acts by boosting the Notch signaling pathway via two different mechanisms that likely work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway at a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954).
Human | |
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Gene Name: | NOTCH2NLB |
Uniprot: | P0DPK3 |
Entrez: | 100996763 |
Belongs to: |
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NOTCH family |
Notch homolog 2 N-terminal-like protein B
Mass (kDA):
30.097 kDA
Human | |
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Location: | 1q21.2 |
Sequence: | 1; NC_000001.11 (148595855..148712499, complement) |
Expressed in radial glia neural stem cells during cortical development.
Secreted.
PMID: 29856954 by Fiddes I.T., et al. Human-specific NOTCH2NL genes affect Notch signaling and cortical neurogenesis.
PMID: 29856955 by Suzuki I.K., et al. Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.