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Notum Antibodies
AND Notum ELISA kits, Notum Proteins
Many biological assays use antibodies to detect Notum, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Notum in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Notum antibodies...
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Notum Infographic by Boster Bio
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Notum Overview
Facts about Palmitoleoyl-protein carboxylesterase NOTUM.
Palmitoleoyl-protein carboxylesterase NOTUM (Notum)
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by especially mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
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Gene Information
| Mouse | |
|---|---|
| Gene Name: | Notum |
| Uniprot: | Q8R116 |
| Entrez: | 77583 |
Family
| Belongs to: |
|---|
| pectinacetylesterase family |
Alternative Names
EC 3.-; notum pectinacetylesterase homolog (Drosophila); Notum; protein notum homolog
Molecular Weight
Mass (kDA):
56.584 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 E2 |
| Sequence: | 11; |
Tissue Specificity
Widely expressed. Expressed in lung, ovary, kidney, liver and brain. Not detected in thymus, heart, spleen, stomach, skeletal muscle and bone marrow.
Diseases
- Nervousness
- Embryonic Mosaic
- Neoplasms
- Tissue Adhesions
- Muscular Fasciculation
- Malignant Neoplasms
- Congenital Abnormality
- Stenosis
- Cell Transformation, Neoplastic
- Sclerosis
- Prion Diseases
- Neoplasm Metastasis
- Primary Lateral Sclerosis
Pathways
- Lateral Inhibition
- Larval Development
- Neurogenesis
- Wing Disc Development
- Cell Fate Specification
- Localization
- Cell Division
- Segmentation
- Notch Signaling Pathway
- Regeneration
- Cell Adhesion
- Cell Proliferation
- Organ Development
PTMs
- Cleavage
- Gpi Anchoring
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Notum
bosterbio.com/bosterbio-gene-info-cards/Notum
References
PMID: 17967162 by Traister A., et al. Mammalian Notum induces the release of glypicans and other GPI- anchored proteins from the cell surface.
PMID: 25771893 by Zhang X., et al. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation.