NR0B1 Antibodies

AND NR0B1 ELISA kits, NR0B1 Proteins

Many biological assays use antibodies to detect NR0B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR0B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR0B1 antibodies...

We validate the specificity of these antibodies to NR0B1 by testing them on tissues known to express NR0B1 positively and negatively. Browse below to find the NR0B1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for NR0B1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the NR0B1 Western Blot Guide

NR0B1 Infographic by Boster Bio

All NR0B1 Products

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Specificity

Applications

Price

Anti-NR0B1 / DAX1 Monoclonal Antibody

Western blot analysis of NR0B1/DAX1 using anti-NR0B1/DAX1 antibody (M01521)

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01521
100 μl

Anti-DAX-1/NR0B1 Antibody Picoband®

Western blot analysis of DAX-1/NR0B1 using anti-DAX-1/NR0B1 antibody (A01521-2)

IF analysis of DAX-1/NR0B1 using anti-DAX-1/NR0B1 antibody (A01521-2) and anti-Beta Tubulin antibody (M01857-3)

Human

ELISA, IF, ICC, WB

$370
Cat # A01521-2
100 µg/vial

NR0B1 (NM_000475) Human Over-expression Lysate

Human

$628
Cat # LS000190
20 µg, 100 µg

NR0B1 (NM_000475) Human Recombinant Protein

Coomassie blue staining of purified NR0B1 protein

$1249
Cat # PROTP51843
20 µg

NR0B1 Overview

Facts about Nuclear receptor subfamily 0 group B member 1.

NR0B1 3D structure. Source: alphafold

Nuclear receptor subfamily 0 group B member 1 (NR0B1)

Orphan nuclear receptor. Component of a cascade required for the evolution of the hypothalamic-pituitary-adrenal-gonadal axis.

Acts as a coregulatory protein which inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

Gene Information

Human
Gene Name:	NR0B1
Uniprot:	P51843
Entrez:	190

Family

Belongs to:

nuclear hormone receptor family

Alternative Names

AHC; AHCDSS; AHCH; AHX; DAX1; DAX1DAX-1; dosage-sensitive sex reversal; DSS-AHC critical region on the X chromosome protein 1; GTD; HHG; NR0B1; NROB1; nuclear hormone receptor; Nuclear receptor DAX-1; nuclear receptor subfamily 0 group B member 1; nuclear receptor subfamily 0, group B, member 1

Molecular Weight

Mass (kDA):
51.718 kDA

Genomic Context


Human

Location:	Xp21.2
Sequence:	X; NC_000023.11 (30304206..30309390, complement)

Subcellular Localizations

Nucleus. Cytoplasm. Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.

Diseases

Hypoplasia
Congenital Absence Of Adrenal Gland
Congenital Hypoplasia Of Adrenal Gland
Hypogonadism
Adrenal Gland Hypofunction
Hypogonadotropic Hypogonadism
Neoplasms
Pituitary Diseases
Disorders Of Sex Development
Congenital Adrenal Hyperplasia
Addison Disease
Genetic Diseases, X-linked

Adrenal Gland Diseases
Congenital Abnormality
Gonadal Dysgenesis
Malignant Neoplasms
Carcinoma
Infertility
Hyperplasia

Interacting Proteins

ESRRG
NR5A1
RORA

Pathways

Sex Determination
Localization
Sex Differentiation
Secretion
Spermatogenesis
Pathogenesis
Cell Differentiation
Gonad Development
Oncogenesis
Rna Interference
Pigmentation
Ovulation
Granulosa Cell Differentiation

Fertilization
Cell Development
Cell Migration
Receptor Transactivation
Cell Proliferation
Organ Development
Hatching

PTMs

Cleavage
Phosphorylation
Methylation

Reduction
Demethylation
Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR0B1

References

PMID: 7990953 by Zanaria E., et al. An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.

PMID: 8675564 by Guo W., et al. Genomic sequence of the DAX1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.