NR1I3 Antibodies

AND NR1I3 ELISA kits, NR1I3 Proteins

Many biological assays use antibodies to detect NR1I3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR1I3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR1I3 antibodies...

We validate the specificity of these antibodies to NR1I3 by testing them on tissues known to express NR1I3 positively and negatively. Browse below to find the NR1I3 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NR1I3 Infographic by Boster Bio

All NR1I3 Products

Product

Figures

Specificity

Applications

Price

NR1I3 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1813
1 kit, containing one 96-well plate and all necessary reagents

Anti-MB67 NR1I3 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A02858
100ul

Anti-MB67 NR1I3 Antibody

Human

ELISA, IHC, WB

$380
Cat # A02858-1
100ul

Anti-Constitutive androstane receptor (NR1I3) Mouse Monoclonal Antibody [Clone ID: OTI1C6]

Human

IHC, WB

$523
Cat # M02858
100 µl

Constitutive androstane receptor (NR1I3) (NM_001077482) Human Over-expression Lysate

+10

Human

$628
Cat # LS009970
100 µg

NR1I3 Overview

Facts about Nuclear receptor subfamily 1 group I member 3.

NR1I3 3D structure. Source: alphafold

Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.

Gene Information

Human
Gene Name:	NR1I3
Uniprot:	Q14994
Entrez:	9970

Family

Belongs to:

nuclear hormone receptor family

Alternative Names

CAR; CARCAR1; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; Constitutive androstane receptor; MB67; MGC150433; MGC97144; MGC97209; NR1I3; nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67

Molecular Weight

Mass (kDA):
39.942 kDA

Genomic Context


Human

Location:	1q23.3
Sequence:	1; NC_000001.11 (161229666..161238623, complement)

Tissue Specificity

Predominantly expressed in liver.

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Recruited to the cytoplasm by DNAJC7.

Diseases

Malignant Neoplasms
Liver Carcinoma
Carcinoma
Liver Neoplasms
Obesity
Diabetes Mellitus
Cholestasis
Inflammation
Neoplasms
Liver Diseases
Hyperbilirubinemia
Intrahepatic Cholestasis
Hepatomegaly

Diabetes Mellitus, Non-insulin-dependent
Kidney Neoplasm
Renal Cell Carcinoma
Fatty Liver
Leukopenia
Hepatocarcinogenesis
Hypertrophy

Pathways

Transport
Cell Cycle
Energy Homeostasis
Hepatocyte Proliferation
Inflammatory Response
Reverse Transcription
Cell Proliferation
Regeneration
Dna Replication
Cell Growth
Fatty Acid Oxidation
Excretion
Cell Adhesion

Aging
Gluconeogenesis
Glucose Homeostasis
Cell Division
Histone H4 Acetylation
Translation
Drug Transport

PTMs

Phosphorylation
Oxidation

Dephosphorylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1I3

References

PMID: 8114692 by Baes M., et al. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

PMID: 15194709 by Lamba J.K., et al. Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences.