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- Table of Contents
Facts about Nuclear receptor subfamily 2 group F member 6.
Involved in modulation of hormonal reactions. Represses transcriptional activity of this lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene.
Human | |
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Gene Name: | NR2F6 |
Uniprot: | P10588 |
Entrez: | 2063 |
Belongs to: |
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nuclear hormone receptor family |
EAR2; EAR-2ERBA-related gene-2; EAR2nuclear receptor subfamily 2 group F member 6; ERBAL2; ERBAL2v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; NR2F6; nuclear receptor subfamily 2, group F, member 6; V-erbA-related protein 2
Mass (kDA):
42.979 kDA
Human | |
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Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (17231885..17245342, complement) |
Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Nucleus.
Scientists can now use NR2F6 cell based ELISA to determine the NR2F6 markers. The company's ELISA systems feature high-affinity secondary antibodies that allow scientists and engineers to measure protein concentrations in a wide range of biological samples. Boster scientists can also submit species results and applications for product credits. These benefits are available for scientists around the world.
Boster Bio's NR2F6 Cell Based ELIISA Kit allows you to detect NR2F6 within various cell lines and assess the effects of stimulation conditions on NR2F6 transcription. The kit combines Anti-NR2F6 antibodies with HRP-conjugated secondary antibodies. The secondary antibodies are conjugated to the HRP enzyme, which catalyzes a colorimetric response upon addition of a substrate. You can also use the kit to provide multiple methods for normalization to determine the exact protein levels in a sample.
Boster Bio's NR2F6 Cell Based ELISA Kit offers high-sensitivity and picogram-level ELISA. It has been validated for a variety of samples and is compatible with multiple platforms, including immunofluorescent and immunohistochemistry. Images and validation procedures are available upon request. Boster Bio NR2F6 Cell Based ELISA Kit provides Supervision, a polymer-based secondary antigen that can be used to save up to 30 minutes of IHC. It also includes tebubio's technical support.
Boster Bio NR2F6 ELISA Kit - A 96-Well Microplate with a 10x TBS, 50x and 15x Wash Buffer. The reagents as well as the cells are supplied in a clear-bottom Microplate of 96-wells with 10x and 50x TBS respectively. The boster bio NR2F6 Cell Based ELISA Kit includes a mouse monoclonal antibody (Mu-1) and a mouse anti-GAPDH antibody.
NR2F6, an orphan nuclear receptor, is a member of the nuclear receptor subfamily group F, member 6. It is responsible to regulate TCR/CD28 activation and control tumor-infiltrating T lymphocytes. It acts as a transcriptional repressor and blocks DNA from being accessible for activation-induced NFAT/AP-1 transcription elements at cytokine gene locations (IL2 and Ifng), and the promoter to interleukin-2. It also plays an important role in the regulation of the inflammatory response, and the development cancer cells in experimental model.
The NR2F6 marker helps identify a specific antibody molecule and enables the identification of NR2F6-specific IgG. This NR2F6 specific antibody is highly effective at detecting antigens containing NR2F6 metabolites. The detection of high-affinity prima antibodies is also possible with NR2F6. There are also drawbacks. Antibodies with a low NR2F6 level can reduce antigen reactivity.
Scientists can use two different levels or purity in order to reduce monoclonal antibodies. The immunization of animals with synthetic progesterones produces a high-affinity antibody that contains two identical antigen-binding arm. The two arms are paired together in a hinge structure with the NR2F6 specific heavy chain defining a binding wing. The arms can be distinct or identical and are useful for specificity studies in neuroscience, cell biology, and cell biology.
These results are encouraging in vitro and could help improve the effectiveness of immunotherapy against cancer. NR2F6 gene-modified T cells could be used in personalized adoptive therapy. It could also have a positive impact on combinatorial cancer treatments in the future. Recently, the NR2F6 mark was identified as an important immune-checkpoint for treating cancer. This study demonstrates the importance of the NR2F6 inhibitory signalsing pathway in the context cancer immunotherapy.
This marker also has the ability to identify most immunoglobulins. It can identify high-affinity primary antibodies and also help to determine the specificity of monoclonal insulin antibodies. This is an important advantage in the evaluation of anti-insulin research. It is likely to increase the effectiveness of cancer diagnostic tests. The NR2F6 mark can be used for reference in the development of immunoglobulins.
Boster Bio NR2F6 ELIISAK is an easy to use, fast and accurate method of detecting NR2F6 human samples. Its 96 Well clear-bottom microplate includes 10x TBS and 15x Wash Buffer. The kit also contains two 100x mouse monoclonal antibodies that detect EAR2/NR2F6.
The human NR2F6 genes encodes the protein NR2F6. The NR2F6 genetic code encodes the NR2F6 NR2F6. Its abnormal expression in mice impairs the development of mature red blood cells. This is because excessive NR2F6 blocks the pro-erythroblast stage of blood cell development.
The history of Steven Boster is filled with incredible landmarks. From his first product in 1993, he has been developing products in the field of immunohistochemistry, IHC, and hundreds of primary antibodies. He has been able to build one of China's most respected catalog antibody companies. In the late nineties, he developed the ELISA platform, PicoKine(tm), which uses proprietary trade secrets to deliver high-sensitivity ELISA kits.
Steve Boster died on June 26, 2022. He was born to Evelyn and James Meier in Joliet. He was a U.S. Army veteran and a Concordia Hall member in Staunton, VA. He is survived by two daughters, Natosha Poeck and Crystal Boster and six grandchildren. His other family members are his two sisters, Kimberly Blanton & Tammy, as well his brother Jack.
PMID: 2905047 by Miyajima N., et al. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.
PMID: 10644740 by Zhang Y., et al. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.