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- Table of Contents
NR4A1 Antibodies
AND NR4A1 ELISA kits, NR4A1 Proteins
Many biological assays use antibodies to detect NR4A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR4A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR4A1 antibodies...
Designing a Western blot for NR4A1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NR4A1 Western Blot GuideNR4A1 Infographic by Boster Bio
All NR4A1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1410
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1410
1 kit, containing one 96-well plate and all necessary reagents
NR4A1 Overview
Facts about Nuclear receptor subfamily 4 group A member 1.
Nuclear receptor subfamily 4 group A member 1 (NR4A1)
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration.
Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.
Gene Information
| Human | |
|---|---|
| Gene Name: | NR4A1 |
| Uniprot: | P22736 |
| Entrez: | 3164 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
Early response protein NAK1; GFRP1ST-59; growth factor-inducible nuclear protein N10; HMR; HMRNP10; hormone receptor; MGC9485; N10; NAK1; NAK-1; NGFIB alpha; NGFI-B alpha; NGFIB; NR4A1; Nuclear hormone receptor NUR/77; nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; steroid receptor TR3; Testicular receptor 3; TR3 orphan receptor; TR3
Molecular Weight
Mass (kDA):
64.463 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (52022832..52059507) |
Tissue Specificity
Fetal muscle and adult liver, brain and thyroid.
Subcellular Localizations
Nucleus. Cytoplasm. Mitochondrion. Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950).
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Pituitary Diseases
- Leukemia
- Atherosclerosis
- Carcinoma
- Nervousness
- Lymphoma
- Physiological Stress
- Malignant Neoplasm Of Breast
- Lung Neoplasms
Interacting Proteins
- ANKIB1
- BCL2
- BNIP3L
- CDKN2D
- CUTA
- GK
- KRTAP10-5
- LONRF1
- MATR3
- PGBD1
Pathways
- Cell Death
- Cell Cycle
- Localization
- Cell Proliferation
- Secretion
- Cell Growth
- Induction Of Apoptosis
- Nuclear Export
- Pathogenesis
- Rna Interference
- Programmed Cell Death
- Cell Development
- Gluconeogenesis
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Oxidation
- Methylation
- Ubiquitination
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR4A1
bosterbio.com/bosterbio-gene-info-cards/NR4A1
References
PMID: 2283997 by Nakai A., et al. A human early response gene homologous to murine nur77 and rat NGFI- B, and related to the nuclear receptor superfamily.
PMID: 2626032 by Chang C., et al. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.
1 Publications of Boster NR4A1 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.celrep.2019.01.083, NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote D...
*More publications can be found for each product on its corresponding product page