NSMCE3 Antibodies

AND NSMCE3 ELISA kits, NSMCE3 Proteins

Many biological assays use antibodies to detect NSMCE3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NSMCE3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NSMCE3 antibodies...

We validate the specificity of these antibodies to NSMCE3 by testing them on tissues known to express NSMCE3 positively and negatively. Browse below to find the NSMCE3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NSMCE3 Infographic by Boster Bio

All NSMCE3 Products

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Anti-MAGG1 NSMCE3 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A12716
100ul

NSMCE3 Overview

Facts about Non-structural maintenance of chromosomes element 3 homolog.

NSMCE3 3D structure. Source: alphafold

Non-structural maintenance of chromosomes element 3 homolog (NSMCE3)

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.

The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complicated (telosome) components which is proposed to lead to shelterin complicated disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1.

Gene Information

Human
Gene Name:	NSMCE3
Uniprot:	Q96MG7
Entrez:	56160

Family

Belongs to:

No superfamily

Alternative Names

Non-structural maintenance of chromosomes element 3 homolog

Molecular Weight

Mass (kDA):
34.308 kDA

Genomic Context


Human

Location:	15q13.1
Sequence:	15; NC_000015.10 (29264989..29269822, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Cytoplasm. Nucleus. Chromosome, telomere.

Diseases

Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS)

Interacting Proteins

EID3
NSMCE1
NSMCE4A
PJA1

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NSMCE3

References

PMID: 11782285 by Chibuk T.K., et al. A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.

PMID: 18086888 by Taylor E.M., et al. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.