RNA cytosine C(5)-methyltransferase NSUN2 (Nsun2)

RNA methyltransferase that methylates tRNAs, and maybe RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and in positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors (By similarity).

May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.