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- Table of Contents
Facts about tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial.
Mt-tRNA(Met) containing the f(5)c adjustment at the wobble position allows recognition of the AUA codon along with the AUG codon, expanding codon recognition in mitochondrial translation (PubMed:27497299, PubMed:27356879). .
| Human | |
|---|---|
| Gene Name: | NSUN3 |
| Uniprot: | Q9H649 |
| Entrez: | 63899 |

| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |

EC 2.1.1; EC 2.1.1.-; FLJ22109; FLJ22609; MST077; NOL1/NOP2/Sun domain family 3; NOL1/NOP2/Sun domain family member 3; NOL1/NOP2/Sun domain family, member 3; NOP2/Sun domain family, member 3; putative methyltransferase NSUN3
Mass (kDA):
38.244 kDA

| Human | |
|---|---|
| Location: | 3q11.2 |
| Sequence: | 3; NC_000003.12 (94063061..94131832) |
Mitochondrion matrix.



PMID: 27497299 by Haag S., et al. NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.
PMID: 27214402 by Nakano S., et al. NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met).