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- Table of Contents
NTRK3 Antibodies
AND NTRK3 ELISA kits, NTRK3 Proteins
Many biological assays use antibodies to detect NTRK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NTRK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NTRK3 antibodies...
Designing a Western blot for NTRK3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NTRK3 Western Blot GuideDesigning an IHC experiment for NTRK3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NTRK3 IHC GuideNTRK3 Infographic by Boster Bio
All NTRK3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M00706-4
20μL, 40μL, 100μL, 200μL
Cat # M00706-4
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A02502Y516
100ul
Cat # A02502Y516
100ul
NTRK3 Overview
Facts about NT-3 growth factor receptor.
NT-3 growth factor receptor (NTRK3)
Receptor tyrosine kinase involved in nervous system and likely heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | NTRK3 |
| Uniprot: | Q16288 |
| Entrez: | 4916 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.1; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT 3 receptor; NT-3 growth factor receptor; NTRK3; TrkC tyrosine kinase; TrkC; trk-C; TRKCneurotrophin 3 receptor; tyrosine kinase receptor C
Molecular Weight
Mass (kDA):
94.428 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q25.3 |
| Sequence: | 15; NC_000015.10 (87859749..88256796, complement) |
Tissue Specificity
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Fibrosarcoma
- Chromosomal Translocation
- Nervousness
- Cell Transformation, Neoplastic
- Carcinoma
- Infantile Fibrosarcoma
- Depressive Disorder
- Dysequilibrium Syndrome
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Secretory Breast Carcinoma
Interacting Proteins
- DOK6
- SORT1
Pathways
- Cell Proliferation
- Oncogenesis
- Localization
- Metaphase
- Methylation
- Pathogenesis
- Cell Adhesion
- Transport
- Cell Migration
- Brain Development
- Regulation Of Cytoskeleton
- Neurogenesis
PTMs
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTRK3
bosterbio.com/bosterbio-gene-info-cards/NTRK3
References
PMID: 7806211 by McGregor L.M., et al. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
PMID: 7823156 by Shelton D.L., et al. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
3 Publications of Boster NTRK3 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.intimp.2016.02.004, Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a m...
- PubMed ID: 27051345, Expression of neurotrophic factors in injured spinal cord after transplantation ...
- PubMed ID: 2679038, Electro-acupuncture promotes survival, differentiation of the bone marrow mesenc...
*More publications can be found for each product on its corresponding product page