NUAK family SNF1-like kinase 1 (NUAK1)

Serine/threonine-protein kinase involved in various processes like cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of'Ser-464' of LATS1, thereby controlling its stability.

Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to decreased dephosphorylation of myosin MLC2 by myosin PP1.