NUDT21 Infographic
Cleavage and polyadenylation specificity factor subunit 5 Info At a glance, species: Human
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Cleavage and polyadenylation specificity factor subunit 5 (NUDT21)
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Gene Information
| Human | |
|---|---|
| Gene Name: | NUDT21 |
| Uniprot: | O43809 |
| Entrez: | 11051 |
Family
| Belongs to: |
|---|
| Nudix hydrolase family |
Alternative Names
CFIm25; CFIM25CPSF 25 kDa subunit; cleavage and polyadenylation specific factor 5, 25 kD subunit; cleavage and polyadenylation specific factor 5, 25 kDa; Cleavage and polyadenylation specificity factor 25 kDa subunit; cleavage and polyadenylation specificity factor subunit 5; CPSF25; CPSF5DKFZp686H1588; Nucleoside diphosphate-linked moiety X motif 21; nudix (nucleoside diphosphate linked moiety X)-type motif 21; Nudix motif 21; pre-mRNA cleavage factor Im (25kD); Pre-mRNA cleavage factor Im 25 kDa subunit; pre-mRNA cleavage factor Im, 25kD subunit
Molecular Weight
Mass (kDA):
26.227 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q13 |
| Sequence: | 16; NC_000016.10 (56429133..56451332, complement) |
Tissue Specificity
Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763).
Diseases
- Leukemia
Interacting Proteins
- ATXN1
- CARM1
- CPSF6
- CPSF7
- GOLGA2
- MYL6
- TRIM27
Pathways
- Drug Resistance
- Spermatogenesis
PTMs
- Acetylation
bosterbio.com/bosterbio-gene-info-cards/NUDT21
References
PMID: 9659921 by Rueegsegger U., et al. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.
PMID: 8626397 by Rueegsegger U., et al. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.
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