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- Table of Contents
NUMA1 Antibodies
AND NUMA1 ELISA kits, NUMA1 Proteins
Many biological assays use antibodies to detect NUMA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NUMA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NUMA1 antibodies...
Designing an IHC experiment for NUMA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NUMA1 IHC GuideNUMA1 Infographic by Boster Bio
All NUMA1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02018-1
100 µg/vial
Cat # A02018-1
100 µg/vial
Anti-NuMA NUMA1 Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02018-1
100 μl
Cat # M02018-1
100 μl
NUMA1 Overview
Facts about Nuclear mitotic apparatus protein 1.
Nuclear mitotic apparatus protein 1 (NUMA1)
Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which can be vital for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313).
Plays a role in the creation of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(I) alpha proteins, that regulates the recruitment and anchorage of this dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and thus regulates the appropriate oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553).
Gene Information
| Human | |
|---|---|
| Gene Name: | NUMA1 |
| Uniprot: | Q14980 |
| Entrez: | 4926 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
centrophilin stabilizes mitotic spindle in mitotic cells; NMP-22; nuclear mitotic apparatus protein 1; NuMA protein; NuMA; NUMA1; SP-H Antigen; structural nuclear protein
Molecular Weight
Mass (kDA):
238.26 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.4 |
| Sequence: | 11; NC_000011.10 (72002864..72080693, complement) |
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cell cortex. Cell membrane; Lipid-anchor; Cytoplasmic side. Lateral cell membrane. Mitotic cell cycle-dependent shuttling protein that relocalizes from the interphase nucleus to the spindle poles and cell cortex (PubMed:1541636, PubMed:10811826). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). In interphase, resides in the nuclear matrix (PubMed:1541630, PubMed:1541
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Mammary Neoplasms
- Autoimmune Reaction
- Malignant Neoplasm Of Breast
- Autoimmune Diseases
- Aneuploidy
- Acute Promyelocytic Leukemia
- Malignant Paraganglionic Neoplasm
- Chromosomal Translocation
- Sjogren's Syndrome
- Leukemia, Myelocytic, Acute
Interacting Proteins
- CCDC57
- GNAI1
- GPSM2
- Gpsm2
- RAE1
- TERF2IP
Pathways
- Mitosis
- Interphase
- Localization
- Metaphase
- Cell Cycle
- Cell Division
- Spindle Assembly
- Anaphase
- Chromosome Segregation
- Cell Death
- Spindle Organization
- Telophase
- Transport
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- Breast Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUMA1
bosterbio.com/bosterbio-gene-info-cards/NUMA1
References
PMID: 1541630 by Yang C.H., et al. NuMA: an unusually long coiled-coil related protein in the mammalian nucleus.
PMID: 1541636 by Compton D.A., et al. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.