Endonuclease 8-like 1 Antibodies

AND Neil1 ELISA kits, Endonuclease 8-like 1 Proteins

Many biological assays use antibodies to detect Endonuclease 8-like 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endonuclease 8-like 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endonuclease 8-like 1 antibodies...

We validate the specificity of these antibodies to Endonuclease 8-like 1 by testing them on tissues known to express Neil1 positively and negatively. Browse below to find the Neil1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Endonuclease 8-like 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the NEIL1 Western Blot Guide

Neil1 Infographic by Boster Bio

All Neil1 Products

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Specificity

Applications

Price

Anti-Endonuclease 8-like 1 NEIL1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02953
100ul

NEIL1 (NM_024608) Human Over-expression Lysate

Human

$628
Cat # LS079661
20 µg, 100 µg

Human NEIL1 Recombinant Protein

SDS-PAGE

$287
Cat # PROTQ96FI4
Starting from 10ug

Neil1 Overview

Facts about Endonuclease 8-like 1.

Endonuclease 8-like 1 (Neil1)

Acts as DNA glycosylase that recognizes and removes damaged bases. Has a taste for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil.

Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.

Gene Information

Mouse
Gene Name:	Neil1
Uniprot:	Q8K4Q6
Entrez:	72774

Family

Belongs to:

FPG family

Alternative Names

DNA-(apurinic or apyrimidinic site) lyase Neil1; EC 3.2.2.-; EC 4.2.99.18; endonuclease 8-like 1; endonuclease VIII; Endonuclease VIII-like 1; FLJ22402; FPG1DNA glycosylase/AP lyase Neil1; hFPG1; NEH1; nei endonuclease VIII-like 1 (E. coli); Nei homolog 1; NEI1; Nei-like protein 1

Molecular Weight

Mass (kDA):
43.586 kDA

Genomic Context


Mouse

Location:	9\|9 B
Sequence:	9;

Tissue Specificity

Detected in heart, spleen and lung.

Diseases

Malignant Neoplasms
Carcinogenesis
Carcinoma
Neoplasms
Werner Syndrome
Liver Diseases
Colorectal Cancer
Obesity
Endometriosis, Site Unspecified
Neurodegenerative Disorders
Metabolic Syndrome X
Lung Neoplasms
Hypoxia

Premature Aging Syndrome
Adenocarcinoma
Xeroderma
Xeroderma Pigmentosum
Hyperinsulinism
Malignant Neoplasm Of Stomach
Brain Injuries

Pathways

Dna Repair
Aging
Dna Replication
Cell Cycle
Cell Death
Localization
Hypersensitivity
Methylation
Pathogenesis
Dna Protection
Cell Cycle Checkpoint
Stem Cell Differentiation
Brain Development

Oxidative Demethylation
Strand Displacement
Cell Cycle Arrest
Double-strand Break Repair
Inflammatory Response
Reverse Transcription
Mrna Splicing

PTMs

Cleavage
Oxidation
Demethylation

Phosphorylation
Deamination
Methylation

Iodination

Research Areas

Base Excision Repair
DNA Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Neil1

References

PMID: 12200441 by Takao M., et al. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.

PMID: 23434322 by Spruijt C.G., et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.