Nlrp1a Antibodies

AND Nlrp1a ELISA kits, Nlrp1a Proteins

Many biological assays use antibodies to detect Nlrp1a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nlrp1a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nlrp1a antibodies...

We validate the specificity of these antibodies to Nlrp1a by testing them on tissues known to express Nlrp1a positively and negatively. Browse below to find the Nlrp1a antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nlrp1a Infographic by Boster Bio

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Nlrp1a Overview

Facts about NACHT, LRR and PYD domains-containing protein 1a.

Nlrp1a 3D structure. Source: alphafold

NACHT, LRR and PYD domains-containing protein 1a (Nlrp1a)

As a possible sensor component of this NLRP1 inflammasome, plays an essential role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the creation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD.

Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion.

Gene Information

Mouse
Gene Name:	Nlrp1a
Uniprot:	Q2LKU9
Entrez:	195046

Family

Belongs to:

NLRP family

Alternative Names

NACHT, LRR and PYD domains-containing protein 1a

Molecular Weight

Mass (kDA):
134.308 kDA

Genomic Context


Mouse

Location:	11 B4\|11 43.21 cM
Sequence:	11;

Tissue Specificity

Highly expressed in hematopoietic stem cells and progenitor cells of both myeloid and lymphoid origin (PubMed:23219391). The expression is highly strain-dependent. Not expressed in Balb/cJ animals, but widely expressed in C57BL/6J. Expressed in macrophages resistant to Bacillus anthracis lethal toxin, but not in toxin-sensitive macrophages, except in CAST/EiJ strain (PubMed:23506131).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nlrp1a

References

PMID: 16429160 by Boyden E.D., et al. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin.

PMID: 23506131 by Sastalla I., et al. Transcriptional analysis of the three Nlrp1 paralogs in mice.