Nlrp9b Antibodies

AND Nlrp9b ELISA kits, Nlrp9b Proteins

Many biological assays use antibodies to detect Nlrp9b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nlrp9b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nlrp9b antibodies...

We validate the specificity of these antibodies to Nlrp9b by testing them on tissues known to express Nlrp9b positively and negatively. Browse below to find the Nlrp9b antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nlrp9b Infographic by Boster Bio

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Nlrp9b Overview

Facts about NACHT, LRR and PYD domains-containing protein 9B.

Nlrp9b 3D structure. Source: alphafold

NACHT, LRR and PYD domains-containing protein 9B (Nlrp9b)

As the sensor part of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, such as rotavirus, initiates the formation of the inflammasome polymeric complex, made from NLRP9, PYCARD and CASP1.

Recruitment of proCASP1 into the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory reactions.

Gene Information

Mouse
Gene Name:	Nlrp9b
Uniprot:	Q66X22
Entrez:	243874

Family

Belongs to:

No superfamily

Alternative Names

NACHT, LRR and PYD domains-containing protein 9B

Molecular Weight

Mass (kDA):
114.802 kDA

Genomic Context


Mouse

Location:	7\|7 A3
Sequence:	7;

Tissue Specificity

Predominantly expressed in the intestine, including proximal and distal colon, cecum, ileum, jejunum and duodenum (at protein level) (PubMed:26411641, PubMed:28636595). In the ileum, expressed in epithelial cells (PubMed:28636595). Also expressed in oocytes at all follicular stages and in preimplantation embryos (at protein level) (PubMed:15317747, PubMed:26411641). Although expression decreases in preimplantation embryos, it is still detectable in blastocyts (PubMed:26411641).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nlrp9b

References

PMID: 15317747 by Hamatani T., et al. Age-associated alteration of gene expression patterns in mouse oocytes.

PMID: 26411641 by Peng H., et al. NLRP9B protein is dispensable for oocyte maturation and early embryonic development in the mouse.