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- Table of Contents
NME2 Antibodies
AND NME2 ELISA kits, NME2 Proteins
Many biological assays use antibodies to detect NME2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NME2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NME2 antibodies...
Designing a Western blot for NME2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NME2 Western Blot GuideDesigning an IHC experiment for NME2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NME2 IHC GuideNME2 Infographic by Boster Bio
All NME2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1830
100 μg/vial
Cat # PA1830
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01762-1
100 μl/vial
Cat # M01762-1
100 μl/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1403
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1403
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2639
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2639
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2075
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2075
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2047
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2047
1 kit, containing two 96-well plates and all necessary reagents
NME2 Overview
Facts about Nucleoside diphosphate kinase B.
Nucleoside diphosphate kinase B (NME2)
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non- specifically (PubMed:8392752, PubMed:19435876).
Gene Information
| Human | |
|---|---|
| Gene Name: | NME2 |
| Uniprot: | P22392 |
| Entrez: | 4831 |
Family
| Belongs to: |
|---|
| NDK family |
Alternative Names
EC 2.7.13.3; Histidine protein kinase NDKB; MGC2212; NDK B; NDKB; NDP Kinase B2; NDPKB; NDPK-B; NM23B; NM23-H2; NME2; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; protein (NM23) expressed in
Molecular Weight
Mass (kDA):
17.298 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (51165536..51171744) |
Tissue Specificity
Isoform 1 and isoform 3 are ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Isoform 3 is mainly cytoplasmic and isoform 1 and isoform 3 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Diseases
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Myeloid Leukemia
- Melanoma
- Malignant Neoplasm Of Breast
- Myeloid Leukemia, Chronic
- Mammary Neoplasms
- Anemia
- Leukemia, Myelocytic, Acute
Interacting Proteins
- DNM2
- NME1
- NME4
Pathways
- Transport
- Localization
- Cell Cycle
- Telomere Binding
- Intracellular Transport
- Cell Activation
- Cell Migration
- Cell Proliferation
- Circadian Rhythm
- Cell Development
- T Cell Activation
- Mitosis
- Dna Repair
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NME2
bosterbio.com/bosterbio-gene-info-cards/NME2
References
PMID: 1988104 by Stahl J.A., et al. Identification of a second human nm23 gene, nm23-H2.
PMID: 1851158 by Gilles A.-M., et al. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.