Nrros Antibodies

AND Nrros ELISA kits, Nrros Proteins

Many biological assays use antibodies to detect Nrros, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nrros in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nrros antibodies...

We validate the specificity of these antibodies to Nrros by testing them on tissues known to express Nrros positively and negatively. Browse below to find the Nrros antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nrros Infographic by Boster Bio

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Nrros Overview

Facts about Transforming growth factor beta activator LRRC33.

Transforming growth factor beta activator LRRC33 (Nrros)

Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and creation of a stable NOX2 complex.

May play a crucial role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. .

Gene Information

Mouse
Gene Name:	Nrros
Uniprot:	Q8BMT4
Entrez:	224109

Family

Belongs to:

LRRC32/LRRC33 family

Alternative Names

ELLP3030; GARPL1; leucine rich repeat containing 33; leucine-rich repeat-containing protein 33; LRRC33; MGC50789; NRROS; UNQ3030; UNQ3030/PRO9833

Molecular Weight

Mass (kDA):
77.14 kDA

Genomic Context


Mouse

Location:	16\|16 B2
Sequence:	16;

Tissue Specificity

Preferentially expressed in immune organs such as lymph nodes, thymus and spleen. Among leukocytes, expressed at higher level in myeloid cell such as macrophages, neutrophils and dendritic cells.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nrros

References

PMID: 24550525 by Su X., et al. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.

PMID: 24739962 by Noubade R., et al. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.