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- Table of Contents
NUAK1 Antibodies
AND NUAK1 ELISA kits, NUAK1 Proteins
Many biological assays use antibodies to detect NUAK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NUAK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NUAK1 antibodies...
Designing a Western blot for NUAK1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NUAK1 Western Blot GuideNUAK1 Infographic by Boster Bio
All NUAK1 Products
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NUAK1 Overview
Facts about NUAK family SNF1-like kinase 1.
NUAK family SNF1-like kinase 1 (NUAK1)
Serine/threonine-protein kinase involved in various processes like cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of'Ser-464' of LATS1, thereby controlling its stability.
Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to decreased dephosphorylation of myosin MLC2 by myosin PP1.
Gene Information
| Human | |
|---|---|
| Gene Name: | NUAK1 |
| Uniprot: | O60285 |
| Entrez: | 9891 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
AMPK-related protein kinase 5; ARK5; ARK5AMP-activated protein kinase family member 5; EC 2.7.11; EC 2.7.11.1; KIAA0537NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1
Molecular Weight
Mass (kDA):
74.305 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.3 |
| Sequence: | 12; NC_000012.12 (106063347..106140033, complement) |
Tissue Specificity
Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Invasiveness
- Colorectal Cancer
- Neoplasm Metastasis
- Colorectal Neoplasms
- Liver Neoplasms
- Tumor Progression
- Multiple Myeloma
- Cell Transformation, Neoplastic
- Liver Carcinoma
Interacting Proteins
- LATS1
- TP53
Pathways
- Senescence
- Cell Death
- Cellular Senescence
- Energy Homeostasis
- Cell Adhesion
- Cell Proliferation
- Cell Migration
- Myosin Filament Organization
- Localization
- Cell Cycle Arrest
- Glucose Homeostasis
- Mismatch Repair
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUAK1
bosterbio.com/bosterbio-gene-info-cards/NUAK1
References
PMID: 14976552 by Lizcano J.M., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
PMID: 12409306 by Suzuki A., et al. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein.