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- Table of Contents
NVL Antibodies
AND NVL ELISA kits, NVL Proteins
Many biological assays use antibodies to detect NVL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NVL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NVL antibodies...
Designing an IHC experiment for NVL? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NVL IHC GuideNVL Infographic by Boster Bio
All NVL Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05446-3
100 µg/vial
Cat # A05446-3
100 µg/vial
NVL Overview
Facts about Nuclear valosin-containing protein-like.
Nuclear valosin-containing protein-like (NVL)
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity through its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824).
Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of particular assembly variables, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).
Gene Information
| Human | |
|---|---|
| Gene Name: | NVL |
| Uniprot: | O15381 |
| Entrez: | 4931 |
Family
| Belongs to: |
|---|
| AAA ATPase family |
Alternative Names
nuclear valosin-containing protein-like; Nuclear VCP-like protein; nuclear VCP-like; NVLp
Molecular Weight
Mass (kDA):
95.051 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q42.11 |
| Sequence: | 1; NC_000001.11 (224227334..224330189, complement) |
Tissue Specificity
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
Subcellular Localizations
[Isoform 2]: Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.
Diseases
- Lymphoma, Non-hodgkin
- Tuberculosis
- Lymphoma
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Tuberculosis, Bovine
- Mammary Neoplasms
- Neoplasms
- Hemorrhage
- Leukemia
- Oropharyngeal Disorders
- Sclerosis
- Primary Lateral Sclerosis
Pathways
- Transport
- Localization
- Ribosome Biogenesis
- Coagulation
- Cell Proliferation
- Translation
- Oxygen Transport
PTMs
- Acetylation
- Isopeptide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NVL
bosterbio.com/bosterbio-gene-info-cards/NVL
References
PMID: 9286697 by Germain-Lee E.L., et al. NVL: a new member of the AAA family of ATPases localized to the nucleus.
PMID: 15469983 by Nagahama M., et al. NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.