Oas1a Antibodies

AND Oas1a ELISA kits, Oas1a Proteins

Many biological assays use antibodies to detect Oas1a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Oas1a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Oas1a antibodies...

We validate the specificity of these antibodies to Oas1a by testing them on tissues known to express Oas1a positively and negatively. Browse below to find the Oas1a antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Oas1a Infographic by Boster Bio

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Oas1a Overview

Facts about 2'-5'-oligoadenylate synthase 1A.

Oas1a 3D structure. Source: alphafold

2'-5'-oligoadenylate synthase 1A (Oas1a)

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.

Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) resulting in its dimerization and subsequent activation. Activation of RNase L contributes to degradation of cellular in addition to viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication.

Gene Information

Rat
Gene Name:	Oas1a
Uniprot:	Q05961
Entrez:	192281

Family

Belongs to:

2-5A synthase family

Alternative Names

2'-5'-oligoadenylate synthase 1A

Molecular Weight

Mass (kDA):
41.666 kDA

Genomic Context


Rat

Location:	12q16
Sequence:	12;

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Oas1a

References

PMID: 7764002 by Truve E., et al. Transgenic potato plants expressing mammalian 2'-5' oligoadenylate synthetase are protected from potato virus X infection under field conditions.

PMID: 17024523 by Perelygin A.A., et al. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.