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- Table of Contents
N-glycosylase/DNA lyase Antibodies
AND OGG1 ELISA kits, N-glycosylase/DNA lyase Proteins
Many biological assays use antibodies to detect N-glycosylase/DNA lyase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with N-glycosylase/DNA lyase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop N-glycosylase/DNA lyase antibodies...
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OGG1 Infographic by Boster Bio
All OGG1 Products
Product
Figures
Specificity
Applications
Price
Anti-Ogg1 Antibody Picoband®
1 Citations 1 Q&As
Human
IP, IF, IHC, ICC, WB
$370
Cat # A00768-1
100 μg/vial
Cat # A00768-1
100 μg/vial
SDS-PAGE
$250
Cat # PROTO15527
Starting from 20ug
Cat # PROTO15527
Starting from 20ug
Human
Cell Culture
$77
Cat # PROTO15527-2
5ug,20ug,100ug
Cat # PROTO15527-2
5ug,20ug,100ug
OGG1 Overview
Facts about N-glycosylase/DNA lyase.
N-glycosylase/DNA lyase (OGG1)
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA.
Has a beta- lyase activity that nicks DNA 3' to the lesion. .
Gene Information
| Human | |
|---|---|
| Gene Name: | OGG1 |
| Uniprot: | O15527 |
| Entrez: | 4968 |
Family
| Belongs to: |
|---|
| type-1 OGG1 family |
Alternative Names
8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; HOGG1; MMH; MUTMOGH1HMMH; N-glycosylase/DNA lyase; OGG1
Molecular Weight
Mass (kDA):
38.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.3 |
| Sequence: | 3; NC_000003.12 (9749944..9788246) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; [Isoform 1A]: Nucleus.; [Isoform 2A]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinogenesis
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Inflammation
- Colorectal Cancer
- Malignant Squamous Cell Neoplasm
- Neurodegenerative Disorders
Pathways
- Dna Repair
- Aging
- Pathogenesis
- Localization
- Mismatch Repair
- Cell Death
- Cell Proliferation
- Base-excision Repair
- Cell Cycle
- Dna Replication
- Excretion
- Cell Growth
- Transport
PTMs
- Cleavage
- Oxidation
- Phosphorylation
- Methylation
- Acetylation
- Biotinylation
Research Areas
- Base Excision Repair
- Cancer
- Chromatin Research
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OGG1
bosterbio.com/bosterbio-gene-info-cards/OGG1
References
PMID: 9187114 by Aburatani H., et al. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.
PMID: 9207108 by Rosenquist T.A., et al. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.