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- Table of Contents
N-glycosylase/DNA lyase Antibodies
AND OGG1 ELISA kits, N-glycosylase/DNA lyase Proteins
Many biological assays use antibodies to detect N-glycosylase/DNA lyase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with N-glycosylase/DNA lyase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop N-glycosylase/DNA lyase antibodies...
Designing a Western blot for N-glycosylase/DNA lyase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OGG1 Western Blot GuideDesigning an IHC experiment for N-glycosylase/DNA lyase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OGG1 IHC GuideOGG1 Infographic by Boster Bio
All OGG1 Products
Product
Figures
Specificity
Applications
Price
Human
Cell Culture
$77
Cat # PROTO15527-2
5ug,20ug,100ug
Cat # PROTO15527-2
5ug,20ug,100ug
SDS-PAGE
$250
Cat # PROTO15527
Starting from 20ug
Cat # PROTO15527
Starting from 20ug
OGG1 Overview
Facts about N-glycosylase/DNA lyase.
N-glycosylase/DNA lyase (OGG1)
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA.
Has a beta- lyase activity that nicks DNA 3' to the lesion. .
Gene Information
| Human | |
|---|---|
| Gene Name: | OGG1 |
| Uniprot: | O15527 |
| Entrez: | 4968 |
Family
| Belongs to: |
|---|
| type-1 OGG1 family |
Alternative Names
8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; HOGG1; MMH; MUTMOGH1HMMH; N-glycosylase/DNA lyase; OGG1
Molecular Weight
Mass (kDA):
38.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.3 |
| Sequence: | 3; NC_000003.12 (9749944..9788246) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; [Isoform 1A]: Nucleus.; [Isoform 2A]: Mitochondrion.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinogenesis
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Inflammation
- Colorectal Cancer
- Malignant Squamous Cell Neoplasm
- Neurodegenerative Disorders
Pathways
- Dna Repair
- Aging
- Pathogenesis
- Localization
- Mismatch Repair
- Cell Death
- Cell Proliferation
- Base-excision Repair
- Cell Cycle
- Dna Replication
- Excretion
- Cell Growth
- Transport
PTMs
- Cleavage
- Oxidation
- Phosphorylation
- Methylation
- Acetylation
- Biotinylation
Research Areas
- Base Excision Repair
- Cancer
- Chromatin Research
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OGG1
bosterbio.com/bosterbio-gene-info-cards/OGG1
References
PMID: 9187114 by Aburatani H., et al. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.
PMID: 9207108 by Rosenquist T.A., et al. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.