Protein orai-2 Antibodies

AND ORAI2 ELISA kits, Protein orai-2 Proteins

Many biological assays use antibodies to detect Protein orai-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein orai-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein orai-2 antibodies...

We validate the specificity of these antibodies to Protein orai-2 by testing them on tissues known to express ORAI2 positively and negatively. Browse below to find the ORAI2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Protein orai-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ORAI2 Western Blot Guide

ORAI2 Infographic by Boster Bio

All ORAI2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Orai2 Antibody Picoband®

Western blot analysis of Orai2 using anti-Orai2 antibody (A07411-1)

Human

ELISA, WB

$370
Cat # A07411-1
100 μg/vial

Anti-Protein orai-2 ORAI2 Antibody

Western blot analysis of ORAI2 in Jurkat cell lysate with ORAI2 antibody at (A) 1, (B) 2 and (C) 4 μg/mL

Immunocytochemistry of ORAI2 in Jurkat cells with ORAI2 antibody at 5 μg/mL

Immunofluorescence of ORAI2 in Jurkat cells with ORAI2 antibody at 20 μg/mL

Human, Mouse

ELISA, IF, ICC, WB

$481
Cat # A07411
0.1 mg

ORAI2 (NM_001126340) Human Over-expression Lysate

ORAI2 Human Over-expression Lysates NM_001126340

Human

$628
Cat # LS080228
20 µg, 100 µg

ORAI2 Overview

Facts about Protein orai-2.

ORAI2 3D structure. Source: alphafold

Protein orai-2 (ORAI2)

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. .

Gene Information

Human
Gene Name:	ORAI2
Uniprot:	Q96SN7
Entrez:	80228

Family

Belongs to:

Orai family

Alternative Names

CAP-binding protein complex interacting protein 2; CAP-binding protein complex-interacting protein 2; CBCIP2C7orf19FLJ12474; chromosome 7 open reading frame 19; FLJ14733; H_NH0514P08.8; MEM142B; ORAI calcium release-activated calcium modulator 2; protein orai-2; putative protein ORAI2-2; TMEM142B; Transmembrane protein 142BFLJ44818

Molecular Weight

Mass (kDA):
28.57 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (102433530..102456825)

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Immunologic Deficiency Syndromes
Severe Combined Immunodeficiency
Autoimmunity
Thrombus
Malignant Neoplasm Of Breast
Myopathy
Malignant Neoplasms
Neoplasms
Chimera Disorder
Inflammation
Congenital Combined Immunodeficiency
Prion Diseases
Adenoma

Congenital Myopathy (disorder)
Dysplasia
Vascular System Injuries
Anhydrotic Ectodermal Dysplasias
Allergy
Mammary Neoplasms
Parathyroid Gland Adenoma

Pathways

Store-operated Calcium Entry
Secretion
Cell Proliferation
Cytokine Production
Phagocytosis
Transport
Vascular Smooth Muscle Contraction
Regulation Of Store-operated Calcium Entry
Smooth Muscle Contraction
Cytokine Secretion
Ion Transport
Regulation Of Vascular Smooth Muscle Contraction
Pigmentation

Muscle Contraction
Localization
Methylation
Cell Division
Cell Growth
Pathogenesis
Myoblast Differentiation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORAI2

References

PMID: 16807233 by Mercer J.C., et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1.

PMID: 16582901 by Feske S., et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.