ORC2 Antibodies

AND ORC2 ELISA kits, ORC2 Proteins

Many biological assays use antibodies to detect ORC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ORC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ORC2 antibodies...

We validate the specificity of these antibodies to ORC2 by testing them on tissues known to express ORC2 positively and negatively. Browse below to find the ORC2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for ORC2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the ORC2 IHC Guide

ORC2 Infographic by Boster Bio

All ORC2 Products

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Product

Figures

Specificity

Applications

Price

Anti-ORC2 Antibody Picoband®

Western blot analysis of ORC2 using anti-ORC2 antibody (A04350-1)

IHC analysis of ORC2 using anti-ORC2 antibody (A04350-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04350-1
100 µg/vial

ORC2 (NM_006190) Human Over-expression Lysate

Human

$628
Cat # LS004999
20 µg, 100 µg

ORC2 (NM_006190) Human Recombinant Protein

Coomassie blue staining of purified ORC2 protein

$1249
Cat # PROTQ13416
20 µg

ORC2 Overview

Facts about Origin recognition complex subunit 2.

ORC2 3D structure. Source: alphafold

Origin recognition complex subunit 2 (ORC2)

DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet.

ORC is needed to assemble the pre- replication complex essential to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3.

Gene Information

Human
Gene Name:	ORC2
Uniprot:	Q13416
Entrez:	4999

Family

Belongs to:

ORC2 family

Alternative Names

ORC2Lorigin recognition complex subunit 2; origin recognition complex protein 2 homolog; origin recognition complex, subunit 2 (yeast homolog)-like; origin recognition complex, subunit 2 homolog (yeast); origin recognition complex, subunit 2 homolog; origin recognition complex, subunit 2; origin recognition complex, subunit 2-like (yeast); origin recognition complex, subunit 2-like

Molecular Weight

Mass (kDA):
65.972 kDA

Genomic Context


Human

Location:	2q33.1
Sequence:	2; NC_000002.12 (200908977..200963701, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Polyploidy
Hyperammonemia
Neoplasms
Cytogenetic Abnormality
Cell Transformation, Neoplastic
Endoreduplication
Chromosomal Duplication
Genomic Instability
Retinoblastoma
Hyperornithinemia-hyperammonemia-homocitrullinuria Syndrome
Instabilities, Chromosomal

Ataxia
Aneuploidy
Sarcoma
Carcinoma
Angiolymphoid Hyperplasia
Memory Disorders

Interacting Proteins

CDC5L
FOXM1
MCM10
MCM3
ORC1

ORC3
ORC4
ORC5
TERF2

Pathways

Dna Replication
Cell Cycle
S Phase
Mitosis
Localization
Dna Replication Initiation
Cell Division
G1 Phase
M Phase
Metaphase
Interphase
Cell Proliferation
Cell Cycle Arrest

Dna Damage Checkpoint
Plasmid Maintenance
Chromosome Condensation
Oogenesis
Transport
Sister Chromatid Cohesion
Methylation

PTMs

Phosphorylation
Acetylation
Methylation

Dephosphorylation
Ubiquitination
Cleavage

Ribosylation

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORC2

References

PMID: 7502077 by Gavin K.A., et al. Conserved initiator proteins in eukaryotes.

PMID: 8808289 by Takahara K., et al. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.