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- Table of Contents
Protein OS-9 Antibodies
AND OS9 ELISA kits, Protein OS-9 Proteins
Many biological assays use antibodies to detect Protein OS-9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein OS-9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein OS-9 antibodies...
Designing a Western blot for Protein OS-9? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the OS9 Western Blot GuideOS9 Infographic by Boster Bio
All OS9 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M04158-1
100 μl/vial
Cat # M04158-1
100 μl/vial
OS9 Overview
Facts about Protein OS-9.
Protein OS-9 (OS9)
Lectin which operates in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins in addition to improperly folded glycoproteins, keep them at the ER, and transfer them to the ubiquitination machinery and promote their degradation.
Potential targets include TRPV4. .
Gene Information
| Human | |
|---|---|
| Gene Name: | OS9 |
| Uniprot: | Q13438 |
| Entrez: | 10956 |
Family
| Belongs to: |
|---|
| OS-9 family |
Alternative Names
Amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; ERLEC2; erlectin 2; OS-9; osteosarcoma amplified 9, endoplasmic reticulum associated protein; osteosarcoma amplified 9, endoplasmic reticulum lectin; protein OS-9
Molecular Weight
Mass (kDA):
75.562 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3-q14.1 |
| Sequence: | 12; NC_000012.12 (57693955..57721557) |
Tissue Specificity
Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Subcellular Localizations
Endoplasmic reticulum lumen.
Diseases
- Neoplasms
- Osteosarcoma
- Malignant Neoplasms
- Dislocations
- Hypoxia
- Sarcoma
- Physiological Stress
- Von Hippel-lindau Syndrome
- Neoplasms, Experimental
- Neoplasm Metastasis
- Melanoma
- Tumor Progression
Interacting Proteins
- EGLN1
- EGLN3
- HIF1A
Pathways
- Secretory Pathway
- Transport
- Localization
- Protein Folding
- Rna Interference
- Oxygen Homeostasis
- Cell Proliferation
- Response To Hypoxia
- Glycosylation
- Response To Endoplasmic Reticulum Stress
- Conjugation
- Flight
PTMs
- Glycosylation
- Ubiquitination
Research Areas
- Cancer
- Chromatin Research
- Hypoxia
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OS9
bosterbio.com/bosterbio-gene-info-cards/OS9
References
PMID: 8634085 by Su Y.A., et al. Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas.
PMID: 9498564 by Kimura Y., et al. Genomic organization of the OS-9 gene amplified in human sarcomas.