OSBPL8 Antibodies

AND OSBPL8 ELISA kits, OSBPL8 Proteins

Many biological assays use antibodies to detect OSBPL8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OSBPL8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OSBPL8 antibodies...

We validate the specificity of these antibodies to OSBPL8 by testing them on tissues known to express OSBPL8 positively and negatively. Browse below to find the OSBPL8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OSBPL8 Infographic by Boster Bio

All OSBPL8 Products

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Anti-OSBPL8 Antibody Picoband®

Western blot analysis of OSBPL8 using anti-OSBPL8 antibody (A08408-2)

IF analysis of OSBPL8 using anti-OSBPL8 antibody (A08408-2)

Flow Cytometry analysis of HepG2 cells using anti-OSBPL8 antibody (A08408-2)

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A08408-2
100 µg/vial

OSBPL8 Overview

Facts about Oxysterol-binding protein-related protein 8.

OSBPL8 3D structure. Source: alphafold

Oxysterol-binding protein-related protein 8 (OSBPL8)

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine into the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206935).

Binds oxysterol, 25- hydroxycholesterol and cholesterol (PubMed:17428193, PubMed:17991739, PubMed:21698267). .

Gene Information

Human
Gene Name:	OSBPL8
Uniprot:	Q9BZF1
Entrez:	114882

Family

Belongs to:

OSBP family

Alternative Names

MGC126578; MGC133203; MST120; MSTP120; ORP-8; ORP8KIAA1451; OSBP10DKFZp686A11164; OSBP-related protein 8; oxysterol binding protein-like 8; oxysterol-binding protein-related protein 8

Molecular Weight

Mass (kDA):
101.196 kDA

Genomic Context


Human

Location:	12q21.2
Sequence:	12; NC_000012.12 (76351797..76559805, complement)

Tissue Specificity

Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739).

Subcellular Localizations

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane. The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable).; [Isoform 3]: Endoplasmic reticulum membrane; Single-pass membrane protein. Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites.

Diseases

Tissue Adhesions
Mental Disorders
Nervousness

Pathways

Cell Adhesion
Transport
Ras Protein Signal Transduction
Proteolysis
Positive Regulation Of Fat Cell Differentiation
Fatty Acid Transport
System Development
Response To Clozapine
Cell Cycle
Regulation Of Fat Cell Differentiation
Regulation Of Mitosis
Cell Differentiation
Lipid Transport

Visual Perception
Circadian Rhythm
Establishment Of Blood-nerve Barrier
Mitosis
Protein Transport
Wnt Receptor Signaling Pathway
Dna Replication

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OSBPL8

References

PMID: 11735225 by Jaworski C.J., et al. A family of 12 human genes containing oxysterol-binding domains.

PMID: 11483621 by Lehto M., et al. The OSBP-related protein family in humans.