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- Table of Contents
Facts about Otoferlin.
Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).
Human | |
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Gene Name: | OTOF |
Uniprot: | Q9HC10 |
Entrez: | 9381 |
Belongs to: |
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ferlin family |
AUNB1; DFNB6; DFNB9; EC 2.7.10.1; EC 4.2.1.11; FER1L2NSRD9; Fer-1-like protein 2; otoferlin
Mass (kDA):
226.753 kDA
Human | |
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Location: | 2p23.3 |
Sequence: | 2; NC_000002.12 (26457203..26558756, complement) |
Isoform 1 and isoform 3 are found in adult brain. Isoform 2 is expressed in the fetus and in adult brain, heart, placenta, skeletal muscle and kidney.
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell junction, synapse, presynaptic cell membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Detected at basolateral cell membrane with synaptic vesicles surrounding the ribbon and at the presynaptic plasma membrane in the inner hair cells (IHCs)
Are you interested in learning more about OTOF Markers? Check out our article to find out more about Boster Bio's OTOF Marker. We will also go over the specifics and conditions for OTOF marker replacement and Boster Bio. In this article, we'll talk about how Boster Bio sets its price. This is due to the large demand for this marker. The prices below do not include freight, packing sales tax, packing import duty. Prices are subject to change without notice. Boster Biotechnology will inform you of any price change prior to the dispatch of your order.
The OTOF Marker has been widely employed in molecular biology research for over 25 years, and the Boster Microplate Reader allows the researcher to identify the Optical Transducer of Ozone (OTO) in biological samples. This marker can be employed in experiments to identify biological signals like DNA. Furthermore, it works with 0.5 1 ml to 0.5 ul volumes of Aqueous solutions. A multichannel pipette is recommended for larger samples. Boster products come with no-cost credits for the product, so you can show your results to colleagues and friends.
When using the OTOF Marker Be sure to review the instruction manual carefully. A list of recommended uses is available on the Biological Technology website. These examples are not meant to be used as guidelines for specific applications. It is recommended to consult the procedures and protocols of your laboratory prior to using the OTOF Marker. While you're there make sure you take a look at OTOF Marker’s safety and performance data sheet.
The OTOF Marker has an unrestricted guarantee of quality. Boster Biological Technology is able to modify its terms and conditions from time to time. These terms and conditions will be in effect from the date of your order. If the product fails to perform as stated, you must contact the manufacturer for either a replacement or a refund. The company will make every reasonable effort to fix the issue. If this isn't possible, OTOF Marker offers a money-back guarantee.
The OTOF gene encodes 1,230 aa membrane-anchored , cytosolic proteins with three C2 domains that are predicted. Recent research has revealed that the gene is a carrier of the nonsense mutation found in four Lebanese families. The mutation reduces the protein's C-terminus by 500 amino acids. This gene is also related to fer-1, and encodes dysferlin and myoferlin.
First , identify the exon-intron junctions to find a gene's OTOF. Then, designate primers to be around each exon. These exons' OTOF sequences will help you find mutations in DFNB9 affected individuals. To determine if there are mutations, you must identify exons containing the gene. For this study specific primers surround exons one through nine.
The study was approved and conducted by the Institute of Biociencias at Universidade de Sao Paulo. Participants signed a written consent. The OTOF gene was associated with five microsatellite markers. Utilizing fluorescent-labeled primers, PCR products were evaluated using a MegaBACE DNA analysis system that includes Genetic Profiler 1.5. Many diseases can be linked to the OTOF gene.
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The OTOF marker is a molecular tool is widely employed. It is used extensively for research in a wide range of areas which include animal welfare as well as food safety as well as breeding. Despite its popularity, there are still several concerns about OTOF markers being used in the laboratory. To avoid these issues you must be aware about its best uses and advantages. This article will go over some of these issues.
The OTOF marker can be utilized in a myriad of applications such as immunohistochemistry (IHC) and cell phenotyping and genetic analysis. BosterBio's OTOF marker is available in a single-channel or multichannel pipette. Boster Pipettes can disperse 0.5 milliliters of water-based solutions. If you're preparing samples to be used in several experiments, you'll need to make use of a multichannel pipette. And the company offers product credits for you to communicate your results to colleagues.
The OTOF marker can be used to identify biomarkers in a variety of applications such as the diagnosis or treatment of cancer. The OTOF marker is a non-invasive and sensitive method for detecting cancer. Researchers can target cancerous cells by using the OTOF marker's sensitivity as well as its specificity and accuracy. The mTOR inhibitors inside the mTOR pathway could detect human cancer cell markers.
Boster Biological Technology can provide either a replacement product or refund in the event of issues with your OTOF marker. Boster must be informed within 12 months of receiving your product. Once you've notified Boster they will review your protocol and determine whether the issue is a protocol issue. If it is they will offer fair, independent advice and, in the event that it is necessary, they will replace the product.
When you place an order through Boster Biological Technology, you agree to these Terms and Conditions. When you place your order and accept the Terms and Conditions that Boster Biological Technology may update from time to time. These Terms and Conditions are applicable to orders made via the Boster website. However they do not apply to orders placed outside of the United States Patent Office.
Once you've ordered your OTOF marker, you need to look over the packaging and the product. Boster Biological Technology can help you return the wrong OTOF marker if you've purchased it incorrectly. Be sure to follow the storage requirements outlined on the product's datasheet. To avoid the growth of bacterial, it is important to follow the OTOF Marker's requirements for labeling.
PMID: 10192385 by Yasunaga S., et al. A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness.
PMID: 10903124 by Yasunaga S., et al. OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9.