This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
OTUB1 Antibodies
AND OTUB1 ELISA kits, OTUB1 Proteins
Many biological assays use antibodies to detect OTUB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OTUB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OTUB1 antibodies...
Designing an IHC experiment for OTUB1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the OTUB1 IHC GuideOTUB1 Infographic by Boster Bio
All OTUB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A04361-1
100 µg/vial
Cat # A04361-1
100 µg/vial
OTUB1 Overview
Facts about Ubiquitin thioesterase OTUB1.
Ubiquitin thioesterase OTUB1 (OTUB1)
Hydrolase that can specifically remove'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen.
Acts through its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy.
Gene Information
| Human | |
|---|---|
| Gene Name: | OTUB1 |
| Uniprot: | Q96FW1 |
| Entrez: | 55611 |
Family
| Belongs to: |
|---|
| peptidase C65 family |
Alternative Names
Deubiquitinating enzyme OTUB1; EC 3.1.2; EC 3.4.19.12; FLJ20113; FLJ40710; hOTU1; MGC111158; OTB1; OTB1MGC4584; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU1; OTU1OTU-domain Ubal-binding 1; OTUB1; Otubain1; Otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1
Molecular Weight
Mass (kDA):
31.284 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (63985853..63998420) |
Tissue Specificity
Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Kidney Diseases
- Ovarian Neoplasm
- Cell Invasion
- Iga Glomerulonephritis
- Endometrial Neoplasms
- Lupus Nephritis
- Hypoxia
- Endometrial Polyp
- Kidney Fibrosis
- Malignant Paraganglionic Neoplasm
- Yersinia Pseudotuberculosis Infections
Interacting Proteins
- BIRC2
- HIF1AN
- MDM2
- TP53
- UBE2D1
- UBE2D2
- UBE2D3
- UBE2D4
- UBE2E1
- UBE2E2
Pathways
- Cell Proliferation
- Translation
- Cell Cycle
- T Cell Proliferation
- Immune Response
- Dna Repair
- Rna Processing
- Virulence
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OTUB1
bosterbio.com/bosterbio-gene-info-cards/OTUB1
References
PMID: 12704427 by Balakirev M.Y., et al. Otubains: a new family of cysteine proteases in the ubiquitin pathway.
PMID: 14661020 by Soares L., et al. Two isoforms of otubain 1 regulate T cell anergy via GRAIL.