OTULIN Antibodies

AND OTULIN ELISA kits, OTULIN Proteins

Many biological assays use antibodies to detect OTULIN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OTULIN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OTULIN antibodies...

We validate the specificity of these antibodies to OTULIN by testing them on tissues known to express OTULIN positively and negatively. Browse below to find the OTULIN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for OTULIN? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the OTULIN Western Blot Guide

OTULIN Infographic by Boster Bio

All OTULIN Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-OTULIN Antibody Picoband®

6 Citations

IF analysis of OTULIN using anti-OTULIN antibody (A07938-1)

Western blot analysis of OTULIN using anti-OTULIN antibody (A07938-1)

IHC analysis of OTULIN using anti-OTULIN antibody (A07938-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A07938-1
100 μg/vial

FAM105B (OTULIN) (NM_138348) Human Over-expression Lysate

Human

$628
Cat # LS090268
20 µg, 100 µg

OTULINL (NM_019018) Human Over-expression Lysate

Human

$628
Cat # LS054491
20 µg, 100 µg

OTULIN Overview

Facts about Ubiquitin thioesterase otulin.

OTULIN 3D structure. Source: alphafold

Ubiquitin thioesterase otulin (OTULIN)

Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and functions as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:24726323, PubMed:24726327).

Required during angiogenesis, craniofacial and neuronal growth by regulating the canonical Wnt signaling with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF- kappa-B by counteracting activity of the LUBAC complex (PubMed:23746843, PubMed:23806334).

Gene Information

Human
Gene Name:	OTULIN
Uniprot:	Q96BN8
Entrez:	90268

Family

Belongs to:

peptidase C65 family

Alternative Names

FAM105B family with sequence similarity 105, member B; FAM105B; OTULIN

Molecular Weight

Mass (kDA):
40.263 kDA

Genomic Context


Human

Location:	5p15.2
Sequence:	5; NC_000005.10 (14660794..14716552)

Subcellular Localizations

Cytoplasm.

Diseases

Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS)

Interacting Proteins

DAZAP2
FAM168A

PTMs

Acetylation

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OTULIN

References

PMID: 23827681 by Mevissen T.E., et al. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PMID: 23806334 by Fiil B.K., et al. OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.