Prolyl 3-hydroxylase 3 Antibodies

AND P3H3 ELISA kits, Prolyl 3-hydroxylase 3 Proteins

Many biological assays use antibodies to detect Prolyl 3-hydroxylase 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prolyl 3-hydroxylase 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prolyl 3-hydroxylase 3 antibodies...

We validate the specificity of these antibodies to Prolyl 3-hydroxylase 3 by testing them on tissues known to express P3H3 positively and negatively. Browse below to find the P3H3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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P3H3 Infographic by Boster Bio

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Anti-P3H3 antibody

Human, Mouse, Rat

ELISA, IP, WB

$370
Cat # A11410
100 μl/vial

P3H3 Overview

Facts about Prolyl 3-hydroxylase 3.

P3H3 3D structure. Source: alphafold

Prolyl 3-hydroxylase 3 (P3H3)

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is needed for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in bone, skin, tendon, aorta and cornea.

Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.

Gene Information

Human
Gene Name:	P3H3
Uniprot:	Q8IVL6
Entrez:	10536

Family

Belongs to:

leprecan family

Alternative Names

Prolyl 3-hydroxylase 3

Molecular Weight

Mass (kDA):
81.837 kDA

Genomic Context


Human

Location:	12p13.31
Sequence:	12; NC_000012.12 (6828407..6839847)

Tissue Specificity

Detected in fetal cartilage (at protein level) (PubMed:28115524). Weak expression in heart, lung, ovary and skeletal muscle (PubMed:8723724).

Subcellular Localizations

Endoplasmic reticulum.

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P3H3

References

PMID: 8723724 by Ansari-Lari M.A., et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.

PMID: 9074930 by Ansari-Lari M.A., et al. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.