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- Table of Contents
Facts about Prolyl 3-hydroxylase 3.
Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Human | |
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Gene Name: | P3H3 |
Uniprot: | Q8IVL6 |
Entrez: | 10536 |
Belongs to: |
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leprecan family |
Prolyl 3-hydroxylase 3
Mass (kDA):
81.837 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (6828407..6839847) |
Detected in fetal cartilage (at protein level) (PubMed:28115524). Weak expression in heart, lung, ovary and skeletal muscle (PubMed:8723724).
Endoplasmic reticulum.
PMID: 8723724 by Ansari-Lari M.A., et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
PMID: 9074930 by Ansari-Lari M.A., et al. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.