Phosphofurin acidic cluster sorting protein 2 (PACS2)

Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Moreover, in response to apoptotic inducer, translocates BIB into mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death.

May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. .