Pappalysin-2 Antibodies

AND PAPPA2 ELISA kits, Pappalysin-2 Proteins

Many biological assays use antibodies to detect Pappalysin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pappalysin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pappalysin-2 antibodies...

We validate the specificity of these antibodies to Pappalysin-2 by testing them on tissues known to express PAPPA2 positively and negatively. Browse below to find the PAPPA2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PAPPA2 Infographic by Boster Bio

All PAPPA2 Products

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Anti-PLAC3 PAPPA2 Antibody

Western blot analysis of PLAC3 in HeLa cell lysate with PLAC3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Immunocytochemistry of PLAC3 in HeLa cells with PLAC3 antibody at 10 μg/mL

Immunofluorescence of PLAC3 in HeLa cells with PLAC3 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, ICC, WB

$481
Cat # A06838
0.1 mg

PAPPA2 Overview

Facts about Pappalysin-2.

PAPPA2 3D structure. Source: alphafold

Pappalysin-2 (PAPPA2)

Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the'163-Ser-
.

Gene Information

Human
Gene Name:	PAPPA2
Uniprot:	Q9BXP8
Entrez:	60676

Family

Belongs to:

peptidase M43B family

Alternative Names

EC 3.4.24.-; PAPPA2; PAPP-A2; PAPP-A2pappalysin-2; pappalysin 2; Pappalysin2; Pappalysin-2; PAPPE; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1

Molecular Weight

Mass (kDA):
198.539 kDA

Genomic Context


Human

Location:	1q25.2
Sequence:	1; NC_000001.11 (176463159..176845601)

Tissue Specificity

Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.

Subcellular Localizations

Secreted.

Diseases

Pre-eclampsia
Down Syndrome
Trisomy
Hellp Syndrome
Growth Retardation
Chest Pain
Premature Obstetric Labor
Pregnancy Complications
Bleeding Of Vagina
Malignant Neoplasm Of Breast
Hypoxia
High-risk Pregnancy

Uterine Hemorrhage
Infertility
Inflammatory Response
Insulin Resistance
Dysplasia
Myocardial Infarction
Hemolysis (disorder)

Pathways

Proteolysis
Pathogenesis
Parturition
Aging
Localization
Inflammatory Response

PTMs

Cleavage

Phosphorylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAPPA2

References

PMID: 11264294 by Overgaard M.T., et al. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin- like growth factor-binding protein-5 proteinase.

PMID: 11597188 by Page N.M., et al. The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.