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- Table of Contents
PARN Antibodies
AND PARN ELISA kits, PARN Proteins
Many biological assays use antibodies to detect PARN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARN antibodies...
Designing a Western blot for PARN? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PARN Western Blot GuideDesigning an IHC experiment for PARN? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PARN IHC GuidePARN Infographic by Boster Bio
All PARN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A01501-2
100 μg/vial
Cat # A01501-2
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01501
100 μg/vial
Cat # M01501
100 μg/vial
PARN Overview
Facts about Poly(A)-specific ribonuclease PARN.
Poly(A)-specific ribonuclease PARN (PARN)
3'-exoribonuclease which has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is frequently the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development.
Interacts with both the 3'-end poly(A) tail and the 5'-end cap arrangement during degradation, the interaction with the cap structure needing an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons.
Gene Information
| Human | |
|---|---|
| Gene Name: | PARN |
| Uniprot: | O95453 |
| Entrez: | 5073 |
Family
| Belongs to: |
|---|
| CAF1 family |
Alternative Names
DANEC 3.1.13.4; Deadenylating nuclease; Deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease
Molecular Weight
Mass (kDA):
73.451 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.12 |
| Sequence: | 16; NC_000016.10 (14435701..14630286, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Cytoplasm. Nucleus, nucleolus. Some nuclear fraction is nucleolar.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Adenocarcinoma
- Neoplasm Metastasis
- Tissue Adhesions
- Acute Lymphocytic Leukemia
- Insulin Sensitivity
- Insulin Resistance
- Leukemia, Myelocytic, Acute
- Age Related Macular Degeneration
- Hypertensive Disease
Interacting Proteins
- BARD1
- CSTF2
- NCBP1
Pathways
- Translation
- Oocyte Maturation
- Regulation Of Gene Expression
- Cell Cycle
- Hypersensitivity
- Rna Stabilization
- Oogenesis
- Dna Repair
- Localization
- Regulation Of Translation
- Rna Processing
- Germination
- Cell Migration
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARN
bosterbio.com/bosterbio-gene-info-cards/PARN
References
PMID: 9736620 by Koerner C.G., et al. The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.
PMID: 10640832 by Buiting K., et al. The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11-->q13.