Pbk Antibodies

Lymphokine-activated killer T-cell-originated protein kinase (Pbk)

Phosphorylates MAP kinase p38. Seems to be active only in mitosis.

May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity).

Gene Information

Mouse
Gene Name:	Pbk
Uniprot:	Q9JJ78
Entrez:	52033

Family

Belongs to:
protein kinase superfamily

Alternative Names

Cancer/testis antigen 84; CT84MAPKK-like protein kinase; EC 2.7.12.2; FLJ14385; Nori-3PDZ-binding kinase; PDZ binding kinase; serine/threonine protein kinase; Spermatogenesis-related protein kinase; SPKT-LAK cell-originated protein kinase; TOPKlymphokine-activated killer T-cell-originated protein kinase

Molecular Weight

Mass (kDA):
36.745 kDA

Genomic Context

Mouse
Location:	14 D1|14 34.36 cM
Sequence:	14;

Diseases

• Corneal Diseases
• Neoplasms
• Malignant Neoplasms
• Dystrophy
• Fuchs Endothelial Dystrophy
• Edema
• Intraocular Lymphoma
• Cataract
• Corneal Edema
• Carcinoma
• Complete Hearing Loss

• Malignant Paraganglionic Neoplasm
• Tissue Adhesions
• Inflammation
• Bulla
• Infective Disorder
• Cicatrix

Pathways

• Cell Cycle
• Cell Growth
• Cell Proliferation
• Mitosis
• Cell Division
• Transport
• Cell Migration
• Translation
• Cell Adhesion
• Programmed Cell Death
• Neurogenesis
• Cytokinetic Process
• Spermatogenesis

• Cell Cycle Arrest
• Inflammatory Response
• System Development
• Phagocytosis
• Dna Damage Checkpoint
• Cell Differentiation
• Cholesterol Transport

PTMs

• Phosphorylation
• Cleavage

• Oxidation
• Ubiquitination

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pbk

Best Uses Of The PBK Marker

Boster is a great option for those looking for a high-affinity prime antibody. Boster has been in existence for more than a quarter of a century and its primary antibodies are frequently used. Boster antibodies are backed by validated protocols on Western Blotting, Immunohistochemistry, and ELISA. You can trust their performance and quality.

Boster offers high-affinity primary antibodies.

Boster Bio is a market leader in the production of high-affinity primary antibodies. It also makes Reagents for various research applications. The product line of Boster Bio includes WB, ELISA, and IHC Reagents. These antibodies are suitable for a wide variety of research-related applications, including neuroscience, cancer, and inflammation. Boster Bio antibodies will also maintain their biological properties.

In order to satisfy the increasing demand for primary antibodies, Boster Bio has developed a proprietary platform for ELISA, allowing it to offer high-affinity, highly specific, and top-quality ELISA kits. Boster Bio also follows strict standards for the production and testing the antibodies. The company's ELISA kits are made up of high-affinity proteins. They are also available in a 100-ull liquid version.

Boster Bio is a specialist in monoclonal and multiclonal antibodies with high affinity. This lets researchers identify specific proteins in various tissues. Boster Bio offers a broad selection of more than 12,000 antibodies, and every one has been thoroughly tested for use in ELISA and WB applications. In addition, all its products have been tested quantitatively using known levels of recombinant proteins and non-transfected cell line.

The company also provides custom-designed antibody services, such as high-affinity and low-affinity antibodies. Boster Bio's experts are trained in recombinant expression of proteins and hybridoma development. Boster Bio also offers customized antibodies and peptides. The company also provides antigen design and design services at no cost, including those that target specific targets in the neuroscience field. This company is the leader in the production of phospho antibodies and has produced more than 500.

Flow Cytometry is employed in a variety of scientific fields. The sample is comprised of particles and cells. High-affinity antibodies are essential to achieve this. In addition, the company provides high-affinity monoclonal or polyclonal antibodies that have received high citations for the past 25 years. It is the perfect solution for researchers and scientists professionals to study particles and cells. Boster primary antibodies are high-affinity and reliable.

Boster Bio not only provides monoclonal and multiclonal antibody, but also creates custom antibody cell lines. These cell lines are produced in goats. It needs 0.2 mg protein to complete development. These companies also offer contract services. They promise a high-quality monoclonal antibody within two to three months. They also offer conjugation services. They provide high-quality monoclonal antibodies for clinical and research application.

Steven Boster's story

Steve Boster was a man who was devoted to his family above all other things. His sons were his pride and joy, and Boster loved them more than anyone else. He was the first person he called when his car had a problem at 2 am. He would always show up, even in below-freezing temperatures. Boster was kind to his colleagues and his friends by treating them as family members.

After a long fight against COVID-19, Steve Boster died in Madison, WI on June 6 2022. His family members survived him, and he is survived by his two daughters, Natosha Peck and Crystal Boster, six grandchildren, and four brothers, Jack and Sandra Boster. The people who loved his life will miss him greatly. In lieu of flowers you can also plant a tree in his memory.

The best uses of the PBK marker

The intriguing candidate for skin carcinoma research is the TOPK marker PBK. The expression of the protein is connected to mutations in genes that regulate the development of DNA repair pathways. These pathways include homology-directed repair (HDR), non-homologous end joining (NHEJ), and microhomology-mediated end joining, or MMR. The markers ERCC1, BER, and TOPK involve the ERCCs ERCC1 and ERCC6 The TOPK pathway is involved in RAD50 and the XRCC2 genes.

The PBK gene is not only interconnected with a variety of essential genes, but also plays a role in HCC research. A few of these genes are ARAF, LGALS9B, TTK, DLG1, and LRRC47. These proteins are involved in numerous biological processes, molecular roles, and pathways, which include the mitotic cell cycle checkpoint. This marker is also linked with neutrophils and macrophages and chemokines, receptors, and macrophages.