This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Pre-B-cell leukemia transcription factor 1.
May have a role in steroidogenesis and, then, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.
| Human | |
|---|---|
| Gene Name: | PBX1 |
| Uniprot: | P40424 |
| Entrez: | 5087 |

| Belongs to: |
|---|
| TALE/PBX homeobox family |

DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia homeobox 1; pre-B-cell leukemia transcription factor 1; PRL
Mass (kDA):
46.626 kDA

| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (164559184..164886047) |
Expressed in the kidney. Expressed in the endothelial cells of the glomeruli and interstitium (at protein level) (PubMed:28270404). Expressed in all tissues except in cells of the B and T lineage. Expressed strongly in kidney and brain (PubMed:28270404).
Nucleus.





PMID: 1682799 by Monica K., et al. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.
PMID: 11267683 by Thameem F., et al. Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians.