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- Table of Contents
Facts about Proprotein convertase subtilisin/kexin type 4.
Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins like IGF2 (By similarity). May also participate in folliculogenesis from the uterus (PubMed:11164898).
Mouse | |
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Gene Name: | Pcsk4 |
Uniprot: | P29121 |
Entrez: | 18551 |
Belongs to: |
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peptidase S8 family |
DKFZp434B217; EC 3.4.21; EC 3.4.21.75; EC 3.4.21.93; MGC34749; PC4EC 3.4.21.-; Proprotein convertase 4; proprotein convertase subtilisin/kexin type 4; SPC5
Mass (kDA):
73.214 kDA
Mouse | |
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Location: | 10 C1|10 39.72 cM |
Sequence: | 10; |
Expressed abundantly in the testis since postnatal Day 16 (PubMed:1372895, PubMed:16371590, PubMed:21302280). In testis, strongly detected in round and elongated spermatids as well as spermatocytes. Also observed in residual bodies engulfed by Sertoli cells at spermatogenic stages VIII and IX (PubMed:16371590). In ovaries, expressed in macrophage-like cells of the ovarian theca, interstitium and corpora lutea (PubMed:11164898).
The PCSK4 is a protein found in many human tissue. It can also be found in reproductive organs. This article will cover its use in the human urine and uterine fluid. You can read the rest of the article to learn more about the PCSK4 Gene. Find out how to detect this gene in the human reproductive system. Boster Bio has several products that can be used to help researchers identify this protein within human tissues.
A PCSK4 mark is an enzyme found inside the reproductive organs. It is found in the testes, germ cells, and round spermatids. The detection of PCSK4 protein in sperm can serve as a biomarker of quality sperm. The 54 kDa protein PCSK4 is found in high quantities in testes. It can also be detected in human embryos in ejaculate.
PCSK4 can disrupt normal functioning in spermatozoa. PCSK4 antibody compounds may prevent fertilization by disrupting or affecting the acrosome response, which can result in spermatozoa formation. Anti-PCSK4 antibodies can be used as immunocontraceptives to males by inhibiting the activity PCSK4 in spermatozoa.
The 54-kDa PCSK4 molecule was isolated from human spermatozoa using a method called Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis. It was confirmed by Western Blotting. Various studies have shown that PCSK4 is present in spermatozoa acrosomal membrane surfaces. Gyamera Acheampong also discovered that the protein was present in the cauda epididymis.
The antigen for PCSK4 is 54 kDa, and was isolated from the acrosomal membrane of human spermatozoa using a method called Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis. Western blotting also confirmed the presence of PCSK4 from human sperm. Other studies have also confirmed the presence of this protein molecule in the plasma membranes of spermatozoa. In addition, Gyamera-Acheampong et al. PCSK4 molecules isolated from the caudaépididymis of ratsperm.
PCSK4 is an a 54-kDa proteins that can be found in the reproductive system, including the testes. It is also found in the sperm's egg ejaculate. This profile can be used to determine the quality and quantity of sperm. It also plays a crucial role in penetrating the zona pellucida, and human anti-PCSK4 may be a novel male immunocontraceptive.
Boster Bio produces anti-PCSK4 antibody antibodies that are highly specific for antigen. This means they can identify PCSK4 from a variety of ejaculate specimens. Currently, the human PCSK4 antigen CSB-EL017643HU is available for use in immunocontraception and male sperm samples.
PMID: 1372895 by Nakayama K., et al. Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
PMID: 1448111 by Seidah N.G., et al. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.