Lysine-specific demethylase PHF2 (PHF2)

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive alone, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B.

Demethylation of ARID5B contributes to goal the PHF2-ARID5B complicated to target promoters, where PHF2 mediates demethylation of dimethylated'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.