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PHD finger protein 21A Antibodies
AND PHF21A ELISA kits, PHD finger protein 21A Proteins
Many biological assays use antibodies to detect PHD finger protein 21A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PHD finger protein 21A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PHD finger protein 21A antibodies...
Designing a Western blot for PHD finger protein 21A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PHF21A Western Blot GuidePHF21A Infographic by Boster Bio
All PHF21A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A08507-1
100 μg/vial
Cat # A08507-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08519-2
100 μg/vial
Cat # A08519-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08527-1
100 μg/vial
Cat # A08527-1
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08538-1
100 µg/vial
Cat # A08538-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A08534-1
100 μg/vial
Cat # A08534-1
100 μg/vial
PHF21A Overview
Facts about PHD finger protein 21A.
PHD finger protein 21A (PHF21A)
Part of the BHC complicated, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
In the BHC complicated, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of'Lys-4' of histone H3 in vitro, suggesting a function in demethylation regulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PHF21A |
| Uniprot: | Q96BD5 |
| Entrez: | 51317 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHC80a; BHC80BM-006; BRAF35-HDAC complex protein BHC80; KIAA1696BRAF35/HDAC2 complex (80 kDa); PHD finger protein 21A
Molecular Weight
Mass (kDA):
74.854 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (45929319..46121454, complement) |
Tissue Specificity
Highly expressed in brain. Expressed at much lower level in other tissues.
Subcellular Localizations
Nucleus.
Diseases
- Hereditary Multiple Exostoses
- Haploinsufficiency
- Exostoses
- Chromosomal Translocation
- Potocki-shaffer Syndrome
- Craniofacial Abnormalities
- Developmental Delay (disorder)
- Muscle Hypotonia
- Developmental Disabilities
Interacting Proteins
- BANP
- FHL3
- KRT40
- NUP62
- TRAF1
- ZYX
Pathways
- Demethylation
- Methylation
- Chromatin Remodeling
- Stem Cell Differentiation
- Brain Development
- Histone Demethylation
- Establishment Of Sister Chromatid Cohesion
- Chromosome Segregation
- Spermatogenesis
- Anaphase
- Cell Division
- Mrna Splicing
PTMs
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHF21A
bosterbio.com/bosterbio-gene-info-cards/PHF21A
References
PMID: 12032298 by Hakimi M.-A., et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.
PMID: 12493763 by Hakimi M.-A., et al. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.